Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms
dc.date.accessioned | 2022-06-29T17:08:11Z | |
dc.date.available | 2022-06-29T17:08:11Z | |
dc.date.created | 2022-05-29T15:26:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Jami, Eshim S. Hammerschlag, Anke R. Ip, Hill F. Allegrini, Andrea G. Benyamin, Beben Border, Richard Diemer, Elizabeth W. Jiang, Chang Karhunen, Ville Lu, Yi Lu, Qing Mallard, Travis T. Mishra, Pashupati P. Nolte, Ilja M. Palviainen, Teemu Peterson, Roseann E. Sallis, Hannah M. Shabalin, Andrey A. Tate, Ashley E. Thiering, Elisabeth Vilor-Tejedor, Natàlia Wang, Carol Zhou, Ang Adkins, Daniel E. Alemany, Silvia Ask, Helga Chen, Qi Corley, Robin P. Ehli, Erik A. Evans, Luke M. Havdahl, Alexandra Hagenbeek, Fiona A. Hakulinen, Christian Henders, Anjali K. Hottenga, Jouke Jan Korhonen, Tellervo Mamun, Abdullah Marrington, Shelby Neumann, Alexander Rimfeld, Kaili Rivadeneira, Fernando Silberg, Judy L. van Beijsterveldt, Catharina E. Vuoksimaa, Eero Whipp, Alyce M. Tong, Xiaoran Andreassen, Ole Boomsma, Dorret I. Brown, Sandra A. Burt, S. Alexandra Copeland, William Dick, Danielle M. Harden, K. Paige Harris, Kathleen Mullan Hartman, Catharina A. Heinrich, Joachim Hewitt, John K. Hopfer, Christian Hypponen, Elina Jarvelin, Marjo-Riitta Kaprio, Jaakko Keltikangas-Järvinen, Liisa Klump, Kelly L. Krauter, Kenneth Kuja-Halkola, Ralf Larsson, Henrik Lehtimäki, Terho Lichtenstein, Paul Lundström, Sebastian Maes, Hermine H. Magnus, Per Minor Munafò, Marcus R. Najman, Jake M. Njølstad, Pål Rasmus Oldehinkel, Albertine J. Pennell, Craig E. Plomin, Robert Reichborn-Kjennerud, Ted Reynolds, Chandra Rose, Richard J. Smolen, Andrew Snieder, Harold Stallings, Michael Standl, Marie Sunyer, Jordi Tiemeier, Henning Wadsworth, Sally J. Wall, Tamara L. Whitehouse, Andrew J.O. Williams, Gail M. Ystrøm, Eivind Nivard, Michel G. Bartels, Meike Middeldorp, Christel M. . Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms. Journal of the American Academy of Child and Adolescent Psychiatry. 2022, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/94525 | |
dc.description.abstract | Objective To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. Results The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms | |
dc.title.alternative | ENEngelskEnglishGenome-wide association meta-analysis of childhood and adolescent internalizing symptoms | |
dc.type | Journal article | |
dc.creator.author | Jami, Eshim S. | |
dc.creator.author | Hammerschlag, Anke R. | |
dc.creator.author | Ip, Hill F. | |
dc.creator.author | Allegrini, Andrea G. | |
dc.creator.author | Benyamin, Beben | |
dc.creator.author | Border, Richard | |
dc.creator.author | Diemer, Elizabeth W. | |
dc.creator.author | Jiang, Chang | |
dc.creator.author | Karhunen, Ville | |
dc.creator.author | Lu, Yi | |
dc.creator.author | Lu, Qing | |
dc.creator.author | Mallard, Travis T. | |
dc.creator.author | Mishra, Pashupati P. | |
dc.creator.author | Nolte, Ilja M. | |
dc.creator.author | Palviainen, Teemu | |
dc.creator.author | Peterson, Roseann E. | |
dc.creator.author | Sallis, Hannah M. | |
dc.creator.author | Shabalin, Andrey A. | |
dc.creator.author | Tate, Ashley E. | |
dc.creator.author | Thiering, Elisabeth | |
dc.creator.author | Vilor-Tejedor, Natàlia | |
dc.creator.author | Wang, Carol | |
dc.creator.author | Zhou, Ang | |
dc.creator.author | Adkins, Daniel E. | |
dc.creator.author | Alemany, Silvia | |
dc.creator.author | Ask, Helga | |
dc.creator.author | Chen, Qi | |
dc.creator.author | Corley, Robin P. | |
dc.creator.author | Ehli, Erik A. | |
dc.creator.author | Evans, Luke M. | |
dc.creator.author | Havdahl, Alexandra | |
dc.creator.author | Hagenbeek, Fiona A. | |
dc.creator.author | Hakulinen, Christian | |
dc.creator.author | Henders, Anjali K. | |
dc.creator.author | Hottenga, Jouke Jan | |
dc.creator.author | Korhonen, Tellervo | |
dc.creator.author | Mamun, Abdullah | |
dc.creator.author | Marrington, Shelby | |
dc.creator.author | Neumann, Alexander | |
dc.creator.author | Rimfeld, Kaili | |
dc.creator.author | Rivadeneira, Fernando | |
dc.creator.author | Silberg, Judy L. | |
dc.creator.author | van Beijsterveldt, Catharina E. | |
dc.creator.author | Vuoksimaa, Eero | |
dc.creator.author | Whipp, Alyce M. | |
dc.creator.author | Tong, Xiaoran | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Brown, Sandra A. | |
dc.creator.author | Burt, S. Alexandra | |
dc.creator.author | Copeland, William | |
dc.creator.author | Dick, Danielle M. | |
dc.creator.author | Harden, K. Paige | |
dc.creator.author | Harris, Kathleen Mullan | |
dc.creator.author | Hartman, Catharina A. | |
dc.creator.author | Heinrich, Joachim | |
dc.creator.author | Hewitt, John K. | |
dc.creator.author | Hopfer, Christian | |
dc.creator.author | Hypponen, Elina | |
dc.creator.author | Jarvelin, Marjo-Riitta | |
dc.creator.author | Kaprio, Jaakko | |
dc.creator.author | Keltikangas-Järvinen, Liisa | |
dc.creator.author | Klump, Kelly L. | |
dc.creator.author | Krauter, Kenneth | |
dc.creator.author | Kuja-Halkola, Ralf | |
dc.creator.author | Larsson, Henrik | |
dc.creator.author | Lehtimäki, Terho | |
dc.creator.author | Lichtenstein, Paul | |
dc.creator.author | Lundström, Sebastian | |
dc.creator.author | Maes, Hermine H. | |
dc.creator.author | Magnus, Per Minor | |
dc.creator.author | Munafò, Marcus R. | |
dc.creator.author | Najman, Jake M. | |
dc.creator.author | Njølstad, Pål Rasmus | |
dc.creator.author | Oldehinkel, Albertine J. | |
dc.creator.author | Pennell, Craig E. | |
dc.creator.author | Plomin, Robert | |
dc.creator.author | Reichborn-Kjennerud, Ted | |
dc.creator.author | Reynolds, Chandra | |
dc.creator.author | Rose, Richard J. | |
dc.creator.author | Smolen, Andrew | |
dc.creator.author | Snieder, Harold | |
dc.creator.author | Stallings, Michael | |
dc.creator.author | Standl, Marie | |
dc.creator.author | Sunyer, Jordi | |
dc.creator.author | Tiemeier, Henning | |
dc.creator.author | Wadsworth, Sally J. | |
dc.creator.author | Wall, Tamara L. | |
dc.creator.author | Whitehouse, Andrew J.O. | |
dc.creator.author | Williams, Gail M. | |
dc.creator.author | Ystrøm, Eivind | |
dc.creator.author | Nivard, Michel G. | |
dc.creator.author | Bartels, Meike | |
dc.creator.author | Middeldorp, Christel M. | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2027936 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of the American Academy of Child and Adolescent Psychiatry&rft.volume=&rft.spage=1&rft.date=2022 | |
dc.identifier.jtitle | Journal of the American Academy of Child and Adolescent Psychiatry | |
dc.identifier.volume | 61 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 934 | |
dc.identifier.endpage | 945 | |
dc.identifier.doi | https://doi.org/10.1016/j.jaac.2021.11.035 | |
dc.identifier.urn | URN:NBN:no-97065 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0890-8567 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/94525/4/1-s2.0-S0890856722001794-main.pdf | |
dc.type.version | PublishedVersion |
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