dc.date.accessioned | 2022-05-06T15:04:13Z | |
dc.date.available | 2022-05-06T15:04:13Z | |
dc.date.created | 2022-05-03T14:11:45Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Håberg, Siri Eldevik Page, Christian Magnus Lee, Yunsung Nustad, Haakon Egdetveit Magnus, Maria Christine Haftorn, Kristine Løkås Carlsen, Ellen Øen Denault, William Robert Paul Bohlin, Jon Jugessur, Astanand Magnus, Per Minor Gjessing, Håkon Kristian Lyle, Robert . DNA methylation in newborns conceived by assisted reproductive technology. Nature Communications. 2022, 13, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/93887 | |
dc.description.abstract | Abstract Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo implantation. However, it is unknown to what extent ART procedures alter the fetal epigenome. Underlying parental characteristics and subfertility may also play a role. Here we identify differences in cord blood DNA methylation, measured using the Illumina EPIC platform, between 962 ART conceived and 983 naturally conceived singleton newborns. We show that ART conceived newborns display widespread differences in DNA methylation, and overall less methylation across the genome. There were 607 genome-wide differentially methylated CpGs. We find differences in 176 known genes, including genes related to growth, neurodevelopment, and other health outcomes that have been associated with ART. Both fresh and frozen embryo transfer show DNA methylation differences. Associations persist after controlling for parents’ DNA methylation, and are not explained by parental subfertility. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | DNA methylation in newborns conceived by assisted reproductive technology | |
dc.title.alternative | ENEngelskEnglishDNA methylation in newborns conceived by assisted reproductive technology | |
dc.type | Journal article | |
dc.creator.author | Håberg, Siri Eldevik | |
dc.creator.author | Page, Christian Magnus | |
dc.creator.author | Lee, Yunsung | |
dc.creator.author | Nustad, Haakon Egdetveit | |
dc.creator.author | Magnus, Maria Christine | |
dc.creator.author | Haftorn, Kristine Løkås | |
dc.creator.author | Carlsen, Ellen Øen | |
dc.creator.author | Denault, William Robert Paul | |
dc.creator.author | Bohlin, Jon | |
dc.creator.author | Jugessur, Astanand | |
dc.creator.author | Magnus, Per Minor | |
dc.creator.author | Gjessing, Håkon Kristian | |
dc.creator.author | Lyle, Robert | |
cristin.unitcode | 185,15,13,0 | |
cristin.unitname | Matematisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2021043 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=13&rft.spage=1&rft.date=2022 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-022-29540-w | |
dc.identifier.urn | URN:NBN:no-96452 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/93887/1/Haberg_2022_DNA.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 1896 | |
dc.relation.project | NFR/262700 | |