dc.date.accessioned | 2022-04-20T16:40:52Z | |
dc.date.available | 2022-11-11T23:45:49Z | |
dc.date.created | 2021-11-23T09:22:52Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Khoury, Samar Parisien, Marc Thompson, Scott J. Vachon-Presseau, Etienne Roy, Mathieu Mitchell, Amy Winsvold, Bendik K S Skogholt, Anne Heidi Brumpton, Ben Michael Willer, Cristen J. Fors, Egil Andreas Heuch, Ingrid Nielsen, Jonas Bille Storheim, Kjersti Hagen, Knut Nilsen, Kristian Bernhard Hveem, Kristian Fritsche, Lars Thomas, Laurent Pedersen, Linda Margareth Gabrielsen, Maiken Elvestad Johnsen, Marianne Bakke Lie, Marie Holmen, Oddgeir Børte, Sigrid Stensland, Synne Zhou, Wei Mundal, Ingunn Pernille Zwart, John Anker Henrik Kania, Artur Mogil, Jeffrey S. Diatchenko, Luda . Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. Brain. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/93644 | |
dc.description.abstract | Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is unknown. Using genome-wide approaches, we compared genetic determinants of chronic single-site vs. multisite pain in the UK Biobank. We found that different genetic signals underlie chronic single-site and multisite pain with much stronger genetic contributions for the latter. Among 23 loci associated with multisite pain, 9 loci replicated in the HUNT cohort, with the DCC netrin-1 receptor (DCC) as the top gene. Functional genomics identified axonogenesis in brain tissues as the major contributing pathway to chronic multisite pain. Finally, multimodal structural brain imaging analysis showed that DCC is most strongly expressed in subcortical limbic regions and is associated with alterations in the uncinate fasciculus microstructure, suggesting that DCC-dependent axonogenesis may contribute to COPC via cortico-limbic circuits. Keywords: chronic overlapping pain conditions, netrin, uncinate fasciculus | |
dc.language | EN | |
dc.title | Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions | |
dc.type | Journal article | |
dc.creator.author | Khoury, Samar | |
dc.creator.author | Parisien, Marc | |
dc.creator.author | Thompson, Scott J. | |
dc.creator.author | Vachon-Presseau, Etienne | |
dc.creator.author | Roy, Mathieu | |
dc.creator.author | Mitchell, Amy | |
dc.creator.author | Winsvold, Bendik K S | |
dc.creator.author | Skogholt, Anne Heidi | |
dc.creator.author | Brumpton, Ben Michael | |
dc.creator.author | Willer, Cristen J. | |
dc.creator.author | Fors, Egil Andreas | |
dc.creator.author | Heuch, Ingrid | |
dc.creator.author | Nielsen, Jonas Bille | |
dc.creator.author | Storheim, Kjersti | |
dc.creator.author | Hagen, Knut | |
dc.creator.author | Nilsen, Kristian Bernhard | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Fritsche, Lars | |
dc.creator.author | Thomas, Laurent | |
dc.creator.author | Pedersen, Linda Margareth | |
dc.creator.author | Gabrielsen, Maiken Elvestad | |
dc.creator.author | Johnsen, Marianne Bakke | |
dc.creator.author | Lie, Marie | |
dc.creator.author | Holmen, Oddgeir | |
dc.creator.author | Børte, Sigrid | |
dc.creator.author | Stensland, Synne | |
dc.creator.author | Zhou, Wei | |
dc.creator.author | Mundal, Ingunn Pernille | |
dc.creator.author | Zwart, John Anker Henrik | |
dc.creator.author | Kania, Artur | |
dc.creator.author | Mogil, Jeffrey S. | |
dc.creator.author | Diatchenko, Luda | |
cristin.unitcode | 185,53,42,0 | |
cristin.unitname | Nevroklinikken | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1957590 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Brain | |
dc.identifier.pagecount | 33 | |
dc.identifier.doi | https://doi.org/10.1093/brain/awab359 | |
dc.identifier.urn | URN:NBN:no-96178 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0006-8950 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/93644/1/Khoury%2B21%2BBrain%2BGenome-wide%2Banalysis%2Bidentifies%2Bimpaired%2Baxonogenesis%2Bin%2Bchronic%2Boverlapping%2Bpain%2Bconditions%2BSubmitted%2Bmanuscript.pdf | |
dc.type.version | AcceptedVersion | |