Management of arterial partial pressure of carbon dioxide in the frst week after traumatic brain injury: results from the CENTER-TBI study
dc.date.accessioned | 2022-04-01T17:10:53Z | |
dc.date.available | 2022-04-01T17:10:53Z | |
dc.date.created | 2022-02-21T00:31:48Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Citerio, Giuseppe Robba, Chiara Rebora, Paola Petrosino, Matteo Rossi, elenora Malgeri, L Stocchetti, Nino Galimberti, Stefania Menon, David K. Andelic, Nada Andreassen, Lasse Anke, Audny Gabriele Wagner Frisvold, Shirin Helseth, Eirik Røe, Cecilie Røise, Olav Skandsen, Toril Vik, Anne Åkerlund, Cecilia Amrein, Krisztina Antoni, Anna Audibert, Gerard Azouvi, Philippe Azzolini, Maria luisa Bartels, Ronald Barzo, Pal Beauvais, Romuald Beer, Ronny Bellander, Bo-michael Belli, Antonio Benali, Habib Berardino, Maurizio Beretta, Luigi Blaabjerg, Morten Bragge, Peter Brinck, Vibeke Brazinova, Alexandra Brooker, Joanne Brorsson, Camilla Buki, Andras Bullinger, Monika Cabeleira, Manuel Caccioppola, Alessio Calappi, Emiliana Calvi, Maria rosa Cameron, Peter Lozano, Guillermo carbayo Chevallard, Giorgio Carbonara, Marco Chieregato, Arturo Citerio, Giuseppe Cnossen, Maryse Coburn, Mark . Management of arterial partial pressure of carbon dioxide in the frst week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Medicine. 2021, 47, 961-973 | |
dc.identifier.uri | http://hdl.handle.net/10852/93172 | |
dc.description.abstract | Purpose To describe the management of arterial partial pressure of carbon dioxide (PaCO2) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO2 in patients with high intracranial pressure (ICP). Methods Secondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO2 management during the first week of intensive care unit (ICU) after TBI, focusing on the lowest PaCO2 values. We also assessed PaCO2 management in patients with and without ICP monitoring (ICPm), and with and without intracranial hypertension. We evaluated the effect of profound hyperventilation (defined as PaCO2 < 30 mmHg) on long-term outcome. Results We included 1100 patients, with a total of 11,791 measurements of PaCO2 (5931 lowest and 5860 highest daily values). The mean (± SD) PaCO2 was 38.9 (± 5.2) mmHg, and the mean minimum PaCO2 was 35.2 (± 5.3) mmHg. Mean daily minimum PaCO2 values were significantly lower in the ICPm group (34.5 vs 36.7 mmHg, p < 0.001). Daily PaCO2 nadir was lower in patients with intracranial hypertension (33.8 vs 35.7 mmHg, p < 0.001). Considerable heterogeneity was observed between centers. Management in a centre using profound hyperventilation (HV) more frequently was not associated with increased 6 months mortality (OR = 1.06, 95% CI = 0.77–1.45, p value = 0.7166), or unfavourable neurological outcome (OR 1.12, 95% CI = 0.90–1.38, p value = 0.3138). Conclusions Ventilation is manipulated differently among centers and in response to intracranial dynamics. PaCO2 tends to be lower in patients with ICP monitoring, especially if ICP is increased. Being in a centre which more frequently uses profound hyperventilation does not affect patient outcomes. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Management of arterial partial pressure of carbon dioxide in the frst week after traumatic brain injury: results from the CENTER-TBI study | |
dc.type | Journal article | |
dc.creator.author | Citerio, Giuseppe | |
dc.creator.author | Robba, Chiara | |
dc.creator.author | Rebora, Paola | |
dc.creator.author | Petrosino, Matteo | |
dc.creator.author | Rossi, elenora | |
dc.creator.author | Malgeri, L | |
dc.creator.author | Stocchetti, Nino | |
dc.creator.author | Galimberti, Stefania | |
dc.creator.author | Menon, David K. | |
dc.creator.author | Andelic, Nada | |
dc.creator.author | Andreassen, Lasse | |
dc.creator.author | Anke, Audny Gabriele Wagner | |
dc.creator.author | Frisvold, Shirin | |
dc.creator.author | Helseth, Eirik | |
dc.creator.author | Røe, Cecilie | |
dc.creator.author | Røise, Olav | |
dc.creator.author | Skandsen, Toril | |
dc.creator.author | Vik, Anne | |
dc.creator.author | Åkerlund, Cecilia | |
dc.creator.author | Amrein, Krisztina | |
dc.creator.author | Antoni, Anna | |
dc.creator.author | Audibert, Gerard | |
dc.creator.author | Azouvi, Philippe | |
dc.creator.author | Azzolini, Maria luisa | |
dc.creator.author | Bartels, Ronald | |
dc.creator.author | Barzo, Pal | |
dc.creator.author | Beauvais, Romuald | |
dc.creator.author | Beer, Ronny | |
dc.creator.author | Bellander, Bo-michael | |
dc.creator.author | Belli, Antonio | |
dc.creator.author | Benali, Habib | |
dc.creator.author | Berardino, Maurizio | |
dc.creator.author | Beretta, Luigi | |
dc.creator.author | Blaabjerg, Morten | |
dc.creator.author | Bragge, Peter | |
dc.creator.author | Brinck, Vibeke | |
dc.creator.author | Brazinova, Alexandra | |
dc.creator.author | Brooker, Joanne | |
dc.creator.author | Brorsson, Camilla | |
dc.creator.author | Buki, Andras | |
dc.creator.author | Bullinger, Monika | |
dc.creator.author | Cabeleira, Manuel | |
dc.creator.author | Caccioppola, Alessio | |
dc.creator.author | Calappi, Emiliana | |
dc.creator.author | Calvi, Maria rosa | |
dc.creator.author | Cameron, Peter | |
dc.creator.author | Lozano, Guillermo carbayo | |
dc.creator.author | Chevallard, Giorgio | |
dc.creator.author | Carbonara, Marco | |
dc.creator.author | Chieregato, Arturo | |
dc.creator.author | Citerio, Giuseppe | |
dc.creator.author | Cnossen, Maryse | |
dc.creator.author | Coburn, Mark | |
cristin.unitcode | 185,53,42,10 | |
cristin.unitname | Avdeling for fysikalsk medisin og rehabilitering | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2003861 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Intensive Care Medicine&rft.volume=47&rft.spage=961&rft.date=2021 | |
dc.identifier.jtitle | Intensive Care Medicine | |
dc.identifier.volume | 47 | |
dc.identifier.startpage | 961 | |
dc.identifier.endpage | 973 | |
dc.identifier.doi | https://doi.org/10.1007/s00134-021-06470-7 | |
dc.identifier.urn | URN:NBN:no-95750 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0342-4642 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/93172/1/Citerio%2Bet%2Bal%2B134_2021_Article_6470.pdf | |
dc.type.version | PublishedVersion |
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