dc.date.accessioned | 2022-03-26T16:31:45Z | |
dc.date.available | 2022-03-26T16:31:45Z | |
dc.date.created | 2021-06-13T12:30:35Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Sert, M Bilal Kristensen, Gunnar S Balle Kleppe, Andreas Dørum, Anne . Long-term oncological outcomes and recurrence patterns in early-stage cervical cancer treated with minimally invasive versus abdominal radical hysterectomy: The Norwegian Radium Hospital experience. Gynecologic Oncology. 2021, 1-8 | |
dc.identifier.uri | http://hdl.handle.net/10852/92976 | |
dc.description.abstract | Objective
To compare long-term oncological outcomes in early-stage cervical cancer (CC) patients treated with minimally invasive radical hysterectomy (MIRH) versus abdominal radical hysterectomy (ARH), with a focus on recurrence patterns, tumor sizes, and conization.
Methods
This single-institution, retrospective study consisted of stage IA1-IB1 (FIGO 2009) squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma of the cervix, who underwent radical hysterectomy between 2000 and 2017.
Results
Of the 582 patients included, 353 (60.7%) underwent ARH, and 229 (39.3%) MIRH. The median follow-up was 14.4 years in the ARH group and 6.1 years in the MIRH group (p < 0.0001). Among the 96 stage IA patients, only 3 (3.1%) experienced recurrence. Among stage IB1 patients, the risk of recurrence, after adjusting for standard prognostic variables, was twofold higher in the MIRH group versus the ARH group (HR 2.73, 95% CI: 1.56–4.80), and the relative difference was similar in terms of risk of cancer-specific survival (CSS) (HR 3.04, 95% CI: 1.28–7.20) and overall survival (OS) (HR 2.35, 95% CI: 1.21–4.59). In stage IB1 ≤ 2 cm patients without conization MIRH was associated with reduced time to recurrence (TTR) (HR 4.00, 95% CI: 1.67–9.57), CSS (HR 3.71, 95% CI: 1.19–11.58) and OS (HR 3.02, 95% CI: 1.24–7.34). Intraperitoneal combined recurrences accounted for 12 of 30 (40.0%) recurrences in the MIRH group but were not identified after ARH (p = 0.0001).
Conclusions
MIRH was associated with reduced TTR, CSS and OS versus ARH in stage IB1 CC patients. The risk of peritoneal recurrence was high, even for tumors ≤2 cm without conization. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Long-term oncological outcomes and recurrence patterns in early-stage cervical cancer treated with minimally invasive versus abdominal radical hysterectomy: The Norwegian Radium Hospital experience | |
dc.type | Journal article | |
dc.creator.author | Sert, M Bilal | |
dc.creator.author | Kristensen, Gunnar S Balle | |
dc.creator.author | Kleppe, Andreas | |
dc.creator.author | Dørum, Anne | |
cristin.unitcode | 185,15,5,45 | |
cristin.unitname | ML Maskinlæring | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1915438 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Gynecologic Oncology&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Gynecologic Oncology | |
dc.identifier.volume | 162 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 284 | |
dc.identifier.endpage | 291 | |
dc.identifier.doi | https://doi.org/10.1016/j.ygyno.2021.05.028 | |
dc.identifier.urn | URN:NBN:no-95527 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0090-8258 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/92976/1/SertEtAl2021.pdf | |
dc.type.version | PublishedVersion | |