A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates

dc.date.accessioned	2022-03-19T18:13:37Z
dc.date.available	2022-03-19T18:13:37Z
dc.date.created	2021-04-14T16:03:19Z
dc.date.issued	2021
dc.identifier.citation	Perez Garcia, Raul Manuel Grønnevik, Gaute Riss, Patrick . A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates. Organic Letters. 2021, 23(3), 1011-1015
dc.identifier.uri	http://hdl.handle.net/10852/92650
dc.description.abstract	A Cu(I)-mediated fluoro-deamination method for nucleophilic radiofluorination was devised. The method affords fluorinated aromatic products directly from anilines under both no-carrier added and stoichiometric conditions. Isolated radiochemical yields range from 11% to 81% with high radiochemical purities and a molar activity of 58 MBq/nmol. The reaction conditions were implemented successfully in an automated process for production of (S)-4[18F]fluorogluthetimide on a radiosynthesis module.
dc.language	EN
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.title	A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates
dc.type	Journal article
dc.creator.author	Perez Garcia, Raul Manuel
dc.creator.author	Grønnevik, Gaute
dc.creator.author	Riss, Patrick
cristin.unitcode	185,15,12,57
cristin.unitname	Organisk kjemi
cristin.ispublished	true
cristin.fulltext	original
cristin.qualitycode	2
dc.identifier.cristin	1904113
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Organic Letters&rft.volume=23&rft.spage=1011&rft.date=2021
dc.identifier.jtitle	Organic Letters
dc.identifier.volume	23
dc.identifier.issue	3
dc.identifier.startpage	1011
dc.identifier.endpage	1015
dc.identifier.doi	https://doi.org/10.1021/acs.orglett.0c04209
dc.identifier.urn	URN:NBN:no-95205
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	1523-7060
dc.identifier.fulltext	Fulltext https://www.duo.uio.no/bitstream/handle/10852/92650/1/acs.orglett.0c04209.pdf
dc.type.version	PublishedVersion
dc.relation.project	NFR/231553
dc.relation.project	HSØ/2019112