dc.date.accessioned | 2022-03-12T17:53:57Z | |
dc.date.available | 2022-03-12T17:53:57Z | |
dc.date.created | 2021-07-07T09:33:17Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kleppestø, Magne Bjørnerud, Atle Groote, Inge Rasmus Kim, Minjae Vardal, Jonas Larsson, Christopher . Operator dependency of arterial input function in dynamic contrast-enhanced MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/92370 | |
dc.description.abstract | Objective To investigate the effect of inter-operator variability in arterial input function (AIF) definition on kinetic parameter estimates (KPEs) from dynamic contrast-enhanced (DCE) MRI in patients with high-grade gliomas. Methods The study included 118 DCE series from 23 patients. AIFs were measured by three domain experts (DEs), and a population AIF (pop-AIF) was constructed from the measured AIFs. The DE-AIFs, pop-AIF and AUC-normalized DE-AIFs were used for pharmacokinetic analysis with the extended Tofts model. AIF-dependence of KPEs was assessed by intraclass correlation coefficient (ICC) analysis, and the impact on relative longitudinal change in Ktrans was assessed by Fleiss’ kappa (κ). Results There was a moderate to substantial agreement (ICC 0.51–0.76) between KPEs when using DE-AIFs, while AUC-normalized AIFs yielded ICC 0.77–0.95 for Ktrans, kep and ve and ICC 0.70 for vp. Inclusion of the pop-AIF did not reduce agreement. Agreement in relative longitudinal change in Ktrans was moderate (κ = 0.591) using DE-AIFs, while AUC-normalized AIFs gave substantial (κ = 0.809) agreement. Discussion AUC-normalized AIFs can reduce the variation in kinetic parameter results originating from operator input. The pop-AIF presented in this work may be applied in absence of a satisfactory measurement. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Operator dependency of arterial input function in dynamic contrast-enhanced MRI | |
dc.type | Journal article | |
dc.creator.author | Kleppestø, Magne | |
dc.creator.author | Bjørnerud, Atle | |
dc.creator.author | Groote, Inge Rasmus | |
dc.creator.author | Kim, Minjae | |
dc.creator.author | Vardal, Jonas | |
dc.creator.author | Larsson, Christopher | |
cristin.unitcode | 185,53,63,10 | |
cristin.unitname | Avdeling for radiologi-nukleærmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1920606 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Magnetic Resonance Materials in Physics, Biology and Medicine&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Magnetic Resonance Materials in Physics, Biology and Medicine | |
dc.identifier.volume | 35 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 105 | |
dc.identifier.endpage | 112 | |
dc.identifier.pagecount | 8 | |
dc.identifier.doi | https://doi.org/10.1007/s10334-021-00926-z | |
dc.identifier.urn | URN:NBN:no-94962 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0968-5243 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/92370/1/Kleppest%25C3%25B82021_Article_OperatorDependencyOfArterialIn.pdf | |
dc.type.version | PublishedVersion | |