dc.date.accessioned | 2022-03-11T17:54:57Z | |
dc.date.available | 2022-03-11T17:54:57Z | |
dc.date.created | 2021-10-22T20:43:03Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Sundberg, Jonas Pandey, Sushma Giglio, Daniel Holmberg, Erik Kjeller, Göran Kovács, Anikó Sand, Lars Peter Senguven, Burcu Öhman, Jenny Sapkota, Dipak Hasséus, Bengt . Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia. Scientific Reports. 2021, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/92315 | |
dc.description.abstract | Abstract Oral leukoplakia (OL), a potentially malignant disorder, recurs in 40% of cases after surgical removal. Recurrence is a risk factor for malignant transformation. We aimed to examine the prognostic significance of four biomarkers related to cell proliferation: p53, p63, podoplanin (PDPN) and Ki-67 in predicting recurrence. Formalin-fixed-paraffin-embedded specimens from excised OL (n = 73, 33 recurrent; 40 non-recurrent) were collected in a prospective study. Immunohistochemistry was used to visualise expression of p53, p63, PDPN and Ki-67. Image analysis software was used for quantification of p53-, p63- and Ki-67-expressing cells, while PDPN was analysed visually. The expression of all four proteins were higher in recurrent compared with non-recurrent OL, only expression of p53 was statistically significant. In uni- and multivariable Cox regression analyses of individual markers, expression of p63 was significantly associated with higher recurrence risk ( p = 0.047). OL with a combined high expression of both p53 and p63 had a significantly higher risk to recur [Log Rank, p = 0.036; multivariate Cox, HR: 2.48 (1.13–5.44; p = 0.024)]. Combination of p53 and p63 expression may be used as a prognostic biomarker for recurrence of OL. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia | |
dc.type | Journal article | |
dc.creator.author | Sundberg, Jonas | |
dc.creator.author | Pandey, Sushma | |
dc.creator.author | Giglio, Daniel | |
dc.creator.author | Holmberg, Erik | |
dc.creator.author | Kjeller, Göran | |
dc.creator.author | Kovács, Anikó | |
dc.creator.author | Sand, Lars Peter | |
dc.creator.author | Senguven, Burcu | |
dc.creator.author | Öhman, Jenny | |
dc.creator.author | Sapkota, Dipak | |
dc.creator.author | Hasséus, Bengt | |
cristin.unitcode | 185,16,15,0 | |
cristin.unitname | Institutt for oral biologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1947916 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-021-99326-5 | |
dc.identifier.urn | URN:NBN:no-94937 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/92315/1/s41598-021-99326-5.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 20781 | |