dc.date.accessioned | 2022-03-02T17:41:17Z | |
dc.date.available | 2022-03-02T17:41:17Z | |
dc.date.created | 2021-08-26T13:48:07Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Reijnen, Jeroen S. Marthinsen, Jon Bache Tysland, Alf Ole Muller, Christoph Rainer Schönhardt, Irina Andersen, Erlend K F Seierstad, Therese Hole, Knut Håkon . Results from a PI-RADS-based MRI-directed diagnostic pathway for biopsy-naive patients in a non-university hospital. Abdominal Radiology. 2021, 46, 5639-5646 | |
dc.identifier.uri | http://hdl.handle.net/10852/91695 | |
dc.description.abstract | Abstract
Purpose
To assess the safety and performance of a MRI-directed diagnostic pathway for patients with first-time suspicion of prostate cancer in a non-university hospital.
Methods
Between May 2017 and December 2018 all biopsy-naive patients examined in our hospital followed a MRI-directed diagnostic work-up algorithm based on PI-RADS score. In short, PI-RADS 1–2 was generally not biopsied and PI-RADS 3–5 was reviewed by a multidisciplinary team. Patients with PI-RADS 4-5 were all referred to biopsy, either transrectal ultrasound-guided biopsy or MRI in-bore biopsy for small tumors and for sites difficult to access. PI-RADS scores were compared to the histopathology from biopsies and surgical specimens for patients who had prostatectomy. Non-biopsied patients were referred to a safety net monitoring regimen.
Results
Two hundred and ninety-eight men were enrolled. 97 (33%) had PI-RADS 1–2, 44 (15%) had PI-RADS 3, and 157 (53%) had PI-RADS 4–5. 116 (39%) of the patients avoided biopsy. None of these were diagnosed with significant cancer within 2–3.5 years of safety net monitoring. Almost all high ISUP grade groups (≥ 3) were in the PI-RADS 4–5 category (98%). Prostatectomy specimens and systematic biopsies from MRI-negative areas indicated that very few clinically significant cancers were missed by the MRI-directed diagnostic pathway.
Conclusion
Our findings add to evidence that a MRI-directed diagnostic pathway can be safely established in a non-university hospital. The pathway reduced the number of biopsies and reliably detected the site of the most aggressive cancers.
Graphic abstract | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Results from a PI-RADS-based MRI-directed diagnostic pathway for biopsy-naive patients in a non-university hospital | |
dc.type | Journal article | |
dc.creator.author | Reijnen, Jeroen S. | |
dc.creator.author | Marthinsen, Jon Bache | |
dc.creator.author | Tysland, Alf Ole | |
dc.creator.author | Muller, Christoph Rainer | |
dc.creator.author | Schönhardt, Irina | |
dc.creator.author | Andersen, Erlend K F | |
dc.creator.author | Seierstad, Therese | |
dc.creator.author | Hole, Knut Håkon | |
cristin.unitcode | 185,53,63,0 | |
cristin.unitname | Klinikk for radiologi og nukleærmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1928993 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Abdominal Radiology&rft.volume=46&rft.spage=5639&rft.date=2021 | |
dc.identifier.jtitle | Abdominal Radiology | |
dc.identifier.volume | 46 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 5639 | |
dc.identifier.endpage | 5646 | |
dc.identifier.doi | https://doi.org/10.1007/s00261-021-03249-8 | |
dc.identifier.urn | URN:NBN:no-94319 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2366-004X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/91695/1/Reijnen2021_Article_ResultsFromAPI-RADS-basedMRI-d.pdf | |
dc.type.version | PublishedVersion | |