dc.date.accessioned | 2022-02-25T18:45:54Z | |
dc.date.available | 2022-02-25T18:45:54Z | |
dc.date.created | 2021-09-06T09:07:07Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Arnaout, Ramy A. Luning Prak, Eline T. Schwab, Nicholas Rubelt, Florian Greiff, Victor Pavlović, Milena Sandve, Geir Kjetil Ferkingstad Snapkov, Igor Arora, Rohit Bashford-Rogers, Rachael Breden, Felix Bukhari, Syed Ahmad Chan Corrie, Brian Cowell, Lindsay G. Efroni, Sol Gooley, Christopher Heiden, Jason Vander Koguchi, Yoshinobu Langerak, Ton Soon Lim, Thean Mariotti-Ferrandiz, Encarnita Marquez, Susanna Meysman, Pieter Miho, Enkelejda Motwani, Keshav Nouri, Nima Soto, Cinque Stervbo, Ulrik Trück, Johannes van den Ham, Henk-Jan Watson, Corey Weber, Cédric R. . The Future of Blood Testing Is the Immunome. Frontiers in Immunology. 2021, 12:626793, 1-6 | |
dc.identifier.uri | http://hdl.handle.net/10852/91543 | |
dc.description.abstract | It is increasingly clear that an extraordinarily diverse range of clinically important conditions—including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers—leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person’s B cells (antibodies) and T cells. We refer to these as the immunome . Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The Future of Blood Testing Is the Immunome | |
dc.type | Journal article | |
dc.creator.author | Arnaout, Ramy A. | |
dc.creator.author | Luning Prak, Eline T. | |
dc.creator.author | Schwab, Nicholas | |
dc.creator.author | Rubelt, Florian | |
dc.creator.author | Greiff, Victor | |
dc.creator.author | Pavlović, Milena | |
dc.creator.author | Sandve, Geir Kjetil Ferkingstad | |
dc.creator.author | Snapkov, Igor | |
dc.creator.author | Arora, Rohit | |
dc.creator.author | Bashford-Rogers, Rachael | |
dc.creator.author | Breden, Felix | |
dc.creator.author | Bukhari, Syed Ahmad Chan | |
dc.creator.author | Corrie, Brian | |
dc.creator.author | Cowell, Lindsay G. | |
dc.creator.author | Efroni, Sol | |
dc.creator.author | Gooley, Christopher | |
dc.creator.author | Heiden, Jason Vander | |
dc.creator.author | Koguchi, Yoshinobu | |
dc.creator.author | Langerak, Ton | |
dc.creator.author | Soon Lim, Thean | |
dc.creator.author | Mariotti-Ferrandiz, Encarnita | |
dc.creator.author | Marquez, Susanna | |
dc.creator.author | Meysman, Pieter | |
dc.creator.author | Miho, Enkelejda | |
dc.creator.author | Motwani, Keshav | |
dc.creator.author | Nouri, Nima | |
dc.creator.author | Soto, Cinque | |
dc.creator.author | Stervbo, Ulrik | |
dc.creator.author | Trück, Johannes | |
dc.creator.author | van den Ham, Henk-Jan | |
dc.creator.author | Watson, Corey | |
dc.creator.author | Weber, Cédric R. | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1931450 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Immunology&rft.volume=12:626793&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Frontiers in Immunology | |
dc.identifier.volume | 12 | |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2021.626793 | |
dc.identifier.urn | URN:NBN:no-94104 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1664-3224 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/91543/1/Postnr%2B1931450_Arnaout%2Bet%2Bal_Front%2BImmunol-12-626793.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 626793 | |