dc.date.accessioned | 2022-02-17T18:21:16Z | |
dc.date.available | 2022-02-17T18:21:16Z | |
dc.date.created | 2022-01-04T18:12:44Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Ali, Muhammad Giannakopoulou, Eirini Chrysovalantou Li, Yingqian Lehander, Madeleine Virding Culleton, Stina Yang, Weiwen Knetter, Cathrine Odabasi, Mete Can Bollineni, Ravi Chand Yang, Xinbo Foldvari, Zsofia Böschen, Maxi-Lu Taraldsrud, Eli Strønen, Erlend Toebes, Mireille Hillen, Amy Mazzi, Stefania de Ru, Arnoud H. Janssen, George M. C. Kolstad, Arne Tjønnfjord, Geir Erland Lie, Benedicte Alexandra Griffioen, Marieke Lehmann, Sören Osnes, Liv Toril Buechner, Jochen Garcia, K. Christopher Schumacher, Ton N. van Veelen, Peter A. Leisegang, Matthias Jacobsen, Sten Eirik W. Woll, Petter Olweus, Johanna . T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Nature Biotechnology. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/91055 | |
dc.description.abstract | Abstract Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific for peptides from the intracellular lymphoid-specific enzyme terminal deoxynucleotidyl transferase (TdT), presented in the context of HLA-A*02:01, specifically eliminate primary acute lymphoblastic leukemia (ALL) cells of T- and B-cell origin in vitro and in three mouse models of disseminated B-ALL. By contrast, the treatment spares normal peripheral T- and B-cell repertoires and normal myeloid cells in vitro, and in vivo in humanized mice. TdT is an attractive cancer target as it is highly and homogeneously expressed in 80–94% of B- and T-ALLs, but only transiently expressed during normal lymphoid differentiation, limiting on-target toxicity of TdT-specific T cells. TCR-modified T cells targeting TdT may be a promising immunotherapy for B-ALL and T-ALL that preserves normal lymphocytes. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes | |
dc.title.alternative | ENEngelskEnglishT cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes | |
dc.type | Journal article | |
dc.creator.author | Ali, Muhammad | |
dc.creator.author | Giannakopoulou, Eirini Chrysovalantou | |
dc.creator.author | Li, Yingqian | |
dc.creator.author | Lehander, Madeleine | |
dc.creator.author | Virding Culleton, Stina | |
dc.creator.author | Yang, Weiwen | |
dc.creator.author | Knetter, Cathrine | |
dc.creator.author | Odabasi, Mete Can | |
dc.creator.author | Bollineni, Ravi Chand | |
dc.creator.author | Yang, Xinbo | |
dc.creator.author | Foldvari, Zsofia | |
dc.creator.author | Böschen, Maxi-Lu | |
dc.creator.author | Taraldsrud, Eli | |
dc.creator.author | Strønen, Erlend | |
dc.creator.author | Toebes, Mireille | |
dc.creator.author | Hillen, Amy | |
dc.creator.author | Mazzi, Stefania | |
dc.creator.author | de Ru, Arnoud H. | |
dc.creator.author | Janssen, George M. C. | |
dc.creator.author | Kolstad, Arne | |
dc.creator.author | Tjønnfjord, Geir Erland | |
dc.creator.author | Lie, Benedicte Alexandra | |
dc.creator.author | Griffioen, Marieke | |
dc.creator.author | Lehmann, Sören | |
dc.creator.author | Osnes, Liv Toril | |
dc.creator.author | Buechner, Jochen | |
dc.creator.author | Garcia, K. Christopher | |
dc.creator.author | Schumacher, Ton N. | |
dc.creator.author | van Veelen, Peter A. | |
dc.creator.author | Leisegang, Matthias | |
dc.creator.author | Jacobsen, Sten Eirik W. | |
dc.creator.author | Woll, Petter | |
dc.creator.author | Olweus, Johanna | |
cristin.unitcode | 185,53,49,70 | |
cristin.unitname | K. G. Jebsen senter for immunterapi mot kreft - part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1974698 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Biotechnology&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Nature Biotechnology | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1038/s41587-021-01089-x | |
dc.identifier.urn | URN:NBN:no-93679 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1087-0156 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/91055/1/T%2Bcells%2Btargeted%2Bto%2BTdT%2Bkill%2Bleukemic%2Blymphoblasts%2Bwhile%2Bspating%2Bnormal%2Blymphocytes.pdf | |
dc.type.version | PublishedVersion | |