dc.date.accessioned | 2022-02-16T19:18:14Z | |
dc.date.available | 2022-02-16T19:18:14Z | |
dc.date.created | 2021-12-22T13:56:11Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Niemi, Mari E.K. Karjalainen, Juha Liao, Rachel G. Neale, Benjamin M. Daly, Mark Ganna, Andrea Pathak, Gita A. Andrews, Shea J. Kanai, Masahiro Veerapen, Kumar Fernandez-Cadenas, Israel Schulte, Eva C. Striano, Pasquale Afset, Jan Egil Solligård, Erik Damås, Jan Kristian Risnes, Kari Bettini, Laura Rachele Gustad, Lise Tuset Holter, Jan Cato Hov, Johannes Espolin Roksund Karlsen, Tom Hemming Folseraas, Trine Holten, Aleksander Rygh Dyrhol-Riise, Anne Ma Tonby, Kristian Lind, Andreas Müller, Fredrik Dudman, Susanne Gjeruldsen Grimsrud, Marit Mæhle Vadla, May Sissel Myhre, Ronny Kildal, Anders Benjamin Hoff, Dag Arne Lihaug Muller, Karl Erik Heggelund, Lars Bergan, Jonas Skogen, Vegard . Mapping the human genetic architecture of COVID-19. Nature. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/91033 | |
dc.description.abstract | The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Mapping the human genetic architecture of COVID-19 | |
dc.type | Journal article | |
dc.creator.author | Niemi, Mari E.K. | |
dc.creator.author | Karjalainen, Juha | |
dc.creator.author | Liao, Rachel G. | |
dc.creator.author | Neale, Benjamin M. | |
dc.creator.author | Daly, Mark | |
dc.creator.author | Ganna, Andrea | |
dc.creator.author | Pathak, Gita A. | |
dc.creator.author | Andrews, Shea J. | |
dc.creator.author | Kanai, Masahiro | |
dc.creator.author | Veerapen, Kumar | |
dc.creator.author | Fernandez-Cadenas, Israel | |
dc.creator.author | Schulte, Eva C. | |
dc.creator.author | Striano, Pasquale | |
dc.creator.author | Afset, Jan Egil | |
dc.creator.author | Solligård, Erik | |
dc.creator.author | Damås, Jan Kristian | |
dc.creator.author | Risnes, Kari | |
dc.creator.author | Bettini, Laura Rachele | |
dc.creator.author | Gustad, Lise Tuset | |
dc.creator.author | Holter, Jan Cato | |
dc.creator.author | Hov, Johannes Espolin Roksund | |
dc.creator.author | Karlsen, Tom Hemming | |
dc.creator.author | Folseraas, Trine | |
dc.creator.author | Holten, Aleksander Rygh | |
dc.creator.author | Dyrhol-Riise, Anne Ma | |
dc.creator.author | Tonby, Kristian | |
dc.creator.author | Lind, Andreas | |
dc.creator.author | Müller, Fredrik | |
dc.creator.author | Dudman, Susanne Gjeruldsen | |
dc.creator.author | Grimsrud, Marit Mæhle | |
dc.creator.author | Vadla, May Sissel | |
dc.creator.author | Myhre, Ronny | |
dc.creator.author | Kildal, Anders Benjamin | |
dc.creator.author | Hoff, Dag Arne Lihaug | |
dc.creator.author | Muller, Karl Erik | |
dc.creator.author | Heggelund, Lars | |
dc.creator.author | Bergan, Jonas | |
dc.creator.author | Skogen, Vegard | |
cristin.unitcode | 185,53,18,11 | |
cristin.unitname | Avdeling for mikrobiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1971500 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Nature | |
dc.identifier.volume | 600 | |
dc.identifier.issue | 7889 | |
dc.identifier.startpage | 472 | |
dc.identifier.endpage | 477 | |
dc.identifier.doi | https://doi.org/10.1038/s41586-021-03767-x | |
dc.identifier.urn | URN:NBN:no-93633 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0028-0836 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/91033/1/s41586-021-03767-x.pdf | |
dc.type.version | PublishedVersion | |