dc.date.accessioned | 2022-02-11T18:57:39Z | |
dc.date.available | 2022-05-08T22:46:43Z | |
dc.date.created | 2021-12-15T17:32:05Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Slørdahl, Kathinka Klotz, Dagmar Olsen, Jan Åge Skovlund, Eva Undseth, Christine Abildgaard, Heidi L. Brændengen, Morten Nesbakken, Arild Larsen, Stein Gunnar Hanekamp, Bettina Andrea Holmboe, Laila Kampen Dajani Tvedt, Ragnhild Sveen, Anita Lothe, Ragnhild Adelheid Malinen, Eirik Kaasa, Stein Guren, Marianne Grønlie . Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer. Acta Oncologica. 2021, 60(7), 921-930 | |
dc.identifier.uri | http://hdl.handle.net/10852/90818 | |
dc.description.abstract | Background
Squamous cell carcinoma of the anus (SCCA) is a rare malignancy with rising incidence, associated with human papilloma virus (HPV). Chemoradiotherapy (CRT) is the preferred treatment. The purpose was to investigate treatment failure, survival and prognostic factors after CRT.
Material and methods
In this prospective observational study from a large regional centre, 141 patients were included from 2013 to 2017, and 132 were eligible for analysis. The main inclusion criteria were SCCA, planned radiotherapy, and performance status (ECOG) ≤2. Patient characteristics, disease stage, treatment, and treatment response were prospectively registered. Disease-free survival (DFS), overall survival (OS), and locoregional treatment failure after CRT were analysed. Hazard ratios (HRs) were estimated with Cox`s proportional hazards model.
Results
Median follow-up was 54 (range 6–71) months. Eighteen patients (14%) had treatment failures after CRT; of these 10 (8%) had residual tumour, and 8 (6%) relapse as first failure. The first treatment failure was locoregional (11 patients), distant (5 patients), and both (2 patients). Salvage abdomino-perineal resection was performed in 10 patients, 2 had resections of metastases, and 3 both. DFS was 85% at 3 years and 78% at 5 years. OS was 93% at 3 years and 86% at 5 years. In analyses adjusted for age and gender, HPV negative tumours (HR 2.5, p = 0.024), N3 disease (HR 2.6, p = 0.024), and tumour size ≥4 cm (HR 2.4, p = 0.038) were negative prognostic factors for DFS.
Conclusion
State-of-the-art chemoradiotherapy for SCCA resulted in excellent outcomes, and improved survival compared with previous national data, with <15% treatment failures and a 3-year DFS of >80%. | |
dc.language | EN | |
dc.title | Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer | |
dc.type | Journal article | |
dc.creator.author | Slørdahl, Kathinka | |
dc.creator.author | Klotz, Dagmar | |
dc.creator.author | Olsen, Jan Åge | |
dc.creator.author | Skovlund, Eva | |
dc.creator.author | Undseth, Christine | |
dc.creator.author | Abildgaard, Heidi L. | |
dc.creator.author | Brændengen, Morten | |
dc.creator.author | Nesbakken, Arild | |
dc.creator.author | Larsen, Stein Gunnar | |
dc.creator.author | Hanekamp, Bettina Andrea | |
dc.creator.author | Holmboe, Laila Kampen Dajani | |
dc.creator.author | Tvedt, Ragnhild | |
dc.creator.author | Sveen, Anita | |
dc.creator.author | Lothe, Ragnhild Adelheid | |
dc.creator.author | Malinen, Eirik | |
dc.creator.author | Kaasa, Stein | |
dc.creator.author | Guren, Marianne Grønlie | |
cristin.unitcode | 185,53,49,10 | |
cristin.unitname | Avdeling for kreftbehandling | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1969103 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta Oncologica&rft.volume=60&rft.spage=921&rft.date=2021 | |
dc.identifier.jtitle | Acta Oncologica | |
dc.identifier.volume | 60 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 921 | |
dc.identifier.endpage | 930 | |
dc.identifier.doi | https://doi.org/10.1080/0284186X.2021.1918763 | |
dc.identifier.urn | URN:NBN:no-93427 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0284-186X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90818/1/Sl%25C3%25B8rdahl%2BActa%2BOncol.pdf | |
dc.type.version | AcceptedVersion | |
dc.relation.project | KF/190188-2017 | |