dc.date.accessioned | 2022-02-08T15:53:07Z | |
dc.date.available | 2022-02-08T15:53:07Z | |
dc.date.created | 2022-01-14T10:18:54Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | van der Meer, Dennis Kaufmann, Tobias Shadrin, Alexey Makowski, Carolina Frei, Oleksandr Roelfs, Daniel Monereo-Sánchez, Jennifer Linden, David E. J Rokicki, Jaroslav Alnæs, Dag de Leeuw, Christiaan Thompson, Wesley K. Loughnan, Robert Fan, Chun Chieh Westlye, Lars Tjelta Andreassen, Ole Dale, Anders . The genetic architecture of human cortical folding. Science Advances. 2021, 7(51), 1-9 | |
dc.identifier.uri | http://hdl.handle.net/10852/90662 | |
dc.description.abstract | The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization. Sulcal depth is a robust yet understudied measure of localized folding, previously associated with multiple neurodevelopmental disorders. Here, we report the first genome-wide association study of sulcal depth. Through the multivariate omnibus statistical test (MOSTest) applied to vertex-wise measures from 33,748 U.K. Biobank participants (mean age, 64.3 years; 52.0% female), we identified 856 genome-wide significant loci (P < 5 × 10−8). Comparisons with cortical thickness and surface area indicated that sulcal depth has higher locus yield, heritability, and effective sample size. There was a large amount of genetic overlap between these traits, with gene-based analyses indicating strong associations with neurodevelopmental processes. Our findings demonstrate sulcal depth is a promising neuroimaging phenotype that may enhance our understanding of cortical morphology. | |
dc.language | EN | |
dc.publisher | American Association for the Advancement of Science | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | The genetic architecture of human cortical folding | |
dc.type | Journal article | |
dc.creator.author | van der Meer, Dennis | |
dc.creator.author | Kaufmann, Tobias | |
dc.creator.author | Shadrin, Alexey | |
dc.creator.author | Makowski, Carolina | |
dc.creator.author | Frei, Oleksandr | |
dc.creator.author | Roelfs, Daniel | |
dc.creator.author | Monereo-Sánchez, Jennifer | |
dc.creator.author | Linden, David E. J | |
dc.creator.author | Rokicki, Jaroslav | |
dc.creator.author | Alnæs, Dag | |
dc.creator.author | de Leeuw, Christiaan | |
dc.creator.author | Thompson, Wesley K. | |
dc.creator.author | Loughnan, Robert | |
dc.creator.author | Fan, Chun Chieh | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Dale, Anders | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1980996 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science Advances&rft.volume=7&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Science Advances | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 51 | |
dc.identifier.doi | https://doi.org/10.1126/sciadv.abj9446 | |
dc.identifier.urn | URN:NBN:no-93253 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2375-2548 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90662/1/The%2Bgenetic%2Barchitecture%2Bof%2Bhuman%2Bcortical%2Bfolding.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | eabj9446 | |
dc.relation.project | NFR/276081 | |
dc.relation.project | NOTUR/NORSTORE/NS9666S | |