dc.date.accessioned | 2022-02-07T18:56:38Z | |
dc.date.available | 2022-02-07T18:56:38Z | |
dc.date.created | 2021-12-15T12:33:00Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Lerum, Tøri Vigeland Maltzahn, Niklas Aukrust, Pål Trøseid, Marius Nezvalova-Henriksen, Katerina Kåsine, Trine Dyrhol-Riise, Anne Ma Stiksrud, Birgitte Haugli, Mette Blomberg, Bjørn Kittang, Bård Reiakvam Johannessen, Asgeir Hannula, Raisa Aballi, Saad Kildal, Anders Benjamin Eiken, Ragnhild Dahl, Tuva Børresdatter Lund-Johansen, Fridtjof Müller, Fredrik Rivero, Jezabel Rodriguez Meltzer, Carin Einvik, Gunnar Ueland, Thor Olsen, Inge Christoffer Barratt-Due, Andreas Aaløkken, Trond Mogens Skjønsberg, Ole Henning . Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. 2021, 11, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/90608 | |
dc.description.abstract | The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DLCO), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, randomised clinical trial, investigating the efficacy of remdesivir and hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10. DLCO was below the lower limit of normal in 29.6%. Ground-glass opacities were present in 39.8% on chest-CT, parenchymal bands were found in 41.7%. At admission, low pO2/FiO2 ratio, ICU treatment, high viral load, and low antibody levels, were predictors of a poorer pulmonary outcome after 3 months. High levels of matrix metalloproteinase (MMP)-9 during hospitalisation and at 3 months were associated with persistent CT-findings. Except for a negative effect of remdesivir on CAT-score, we found no effect of remdesivir or HCQ on long-term pulmonary outcomes. Three months after hospital admission for COVID-19, a high prevalence of respiratory symptoms, reduced DLCO, and persistent CT-findings was observed. Low pO2/FiO2 ratio, ICU-admission, high viral load, low antibody levels, and high levels of MMP-9 were associated with a worse pulmonary outcome. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9 | |
dc.type | Journal article | |
dc.creator.author | Lerum, Tøri Vigeland | |
dc.creator.author | Maltzahn, Niklas | |
dc.creator.author | Aukrust, Pål | |
dc.creator.author | Trøseid, Marius | |
dc.creator.author | Nezvalova-Henriksen, Katerina | |
dc.creator.author | Kåsine, Trine | |
dc.creator.author | Dyrhol-Riise, Anne Ma | |
dc.creator.author | Stiksrud, Birgitte | |
dc.creator.author | Haugli, Mette | |
dc.creator.author | Blomberg, Bjørn | |
dc.creator.author | Kittang, Bård Reiakvam | |
dc.creator.author | Johannessen, Asgeir | |
dc.creator.author | Hannula, Raisa | |
dc.creator.author | Aballi, Saad | |
dc.creator.author | Kildal, Anders Benjamin | |
dc.creator.author | Eiken, Ragnhild | |
dc.creator.author | Dahl, Tuva Børresdatter | |
dc.creator.author | Lund-Johansen, Fridtjof | |
dc.creator.author | Müller, Fredrik | |
dc.creator.author | Rivero, Jezabel Rodriguez | |
dc.creator.author | Meltzer, Carin | |
dc.creator.author | Einvik, Gunnar | |
dc.creator.author | Ueland, Thor | |
dc.creator.author | Olsen, Inge Christoffer | |
dc.creator.author | Barratt-Due, Andreas | |
dc.creator.author | Aaløkken, Trond Mogens | |
dc.creator.author | Skjønsberg, Ole Henning | |
cristin.unitcode | 185,53,11,11 | |
cristin.unitname | Lungemedisinsk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1968854 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=11&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-021-02547-x | |
dc.identifier.urn | URN:NBN:no-93206 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90608/1/Lerum%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 23205 | |