dc.date.accessioned | 2022-02-05T18:40:11Z | |
dc.date.available | 2022-02-05T18:40:11Z | |
dc.date.created | 2021-09-28T21:58:50Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | O'Connell, Kevin Sean Frei, Oleksandr Bahrami, Shahram Smeland, Olav Bjerkehagen Bettella, Francesco Cheng, Weiqiu Chu, Yunhan Hindley, Guy Lin, Aihua Shadrin, Alexey Barrett, Elizabeth Ann Lagerberg, Trine Vik Steen, Nils Eiel Dale, Anders M. Djurovic, Srdjan Andreassen, Ole A. . Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. 2021, 1-11 | |
dc.identifier.uri | http://hdl.handle.net/10852/90571 | |
dc.description.abstract | Background
A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we applied novel statistical genetic methodologies to better characterize the potential shared genetic architecture between sleep-related phenotypes and psychiatric disorders.
Methods
Using the MiXeR method, which can estimate polygenic overlap beyond genetic correlation, the shared genetic architecture between major psychiatric disorders (bipolar disorder [N = 51,710], depression [N = 480,359], and schizophrenia [N = 77,096]) and sleep-related phenotypes (chronotype [N = 449,734], insomnia [N = 386,533] and sleep duration [N = 446,118]) were quantified on the basis of genetic summary statistics. Furthermore, the conditional/conjunctional false discovery rate framework was used to identify specific shared loci between these phenotypes, for which positional and functional annotation were conducted with FUMA.
Results
Extensive genetic overlap between the sleep-related phenotypes and bipolar disorder (63%–77%), depression (76%–79%), and schizophrenia (64%–79%) was identified, with moderate levels of congruence between most investigated traits (47%–58%). Specific shared loci were identified for all bivariate analyses, and a subset of 70 credible genes were mapped to these shared loci.
Conclusions
The current results provide evidence for substantial polygenic overlap between psychiatric disorders and sleep-related phenotypes, beyond genetic correlation (|rg| = 0.02 to 0.42). Moderate congruency within the shared genetic components suggests a complex genetic relationship and potential subgroups with higher or lower genetic concordance. This work provides new insights and understanding of the shared genetic etiology of sleep-related phenotypes and psychiatric disorders and highlights new opportunities and avenues for future investigation. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes | |
dc.type | Journal article | |
dc.creator.author | O'Connell, Kevin Sean | |
dc.creator.author | Frei, Oleksandr | |
dc.creator.author | Bahrami, Shahram | |
dc.creator.author | Smeland, Olav Bjerkehagen | |
dc.creator.author | Bettella, Francesco | |
dc.creator.author | Cheng, Weiqiu | |
dc.creator.author | Chu, Yunhan | |
dc.creator.author | Hindley, Guy | |
dc.creator.author | Lin, Aihua | |
dc.creator.author | Shadrin, Alexey | |
dc.creator.author | Barrett, Elizabeth Ann | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Steen, Nils Eiel | |
dc.creator.author | Dale, Anders M. | |
dc.creator.author | Djurovic, Srdjan | |
dc.creator.author | Andreassen, Ole A. | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1940158 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological Psychiatry&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Biological Psychiatry | |
dc.identifier.volume | 90 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 621 | |
dc.identifier.endpage | 631 | |
dc.identifier.doi | https://doi.org/10.1016/j.biopsych.2021.07.007 | |
dc.identifier.urn | URN:NBN:no-93167 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0006-3223 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90571/1/Characterizing%2Bthe%2BGenetic%2BOverlap%2BBetween%2BPsychiatric%2BDisorders%2Band%2BSleep-Related%2BPhenotypes.pdf | |
dc.type.version | PublishedVersion | |