dc.date.accessioned | 2022-02-01T08:01:54Z | |
dc.date.available | 2022-02-01T08:01:54Z | |
dc.date.created | 2021-12-02T11:42:02Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Nawaz, Beenish Fromm, Annette Øygarden, Halvor Eide, Geir E Saeed, Sahrai Meijer, Rudy Bots, Michiel L Sand, Kristin M Thomassen, Lars Næss, Halvor Waje-Andreassen, Ulrike . Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study. European Stroke Journal. 2021, 6(4), 374-384 | |
dc.identifier.uri | http://hdl.handle.net/10852/90363 | |
dc.description.abstract | Objectives: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. Methods: Prevalent atherosclerosis was assessed for 385 patients and 260 controls in seven vascular areas by electrocardiogram (ECG), ankle–arm index (AAI) and measurement of right and left carotid and femoral intima-media thickness (cIMT and fIMT) and abdominal aorta plaques (AAP). Clinical end-points were any new CVE (stroke, angina, myocardial infarction or peripheral arterial disease) or death from any cause at 5-year follow-up. All results were sex- and age-adjusted; logistic regression and Cox proportional hazards models were applied. Results: Young patients ≤49 years had prevalent atherosclerosis in 1/2 of males and 1/3 of females. Compared with controls, young female patients showed significantly higher prevalent atherosclerosis, p = 0.024. Ischaemic ECG and mean cIMT were higher in young and middle-aged female patients ( p = 0.044, p = 0.020, p = 0.023 and p <0.001, respectively). Mean fIMT was higher in middle-aged female patients ( p <0.001). Cardiovascular events were associated with ischaemic ECG; AAI ≤0.9, fIMT ≥0.9 mm and increased number of areas with atherosclerosis (NAA) among patients, and with AAP, cIMT ≥0.9 mm, fIMT ≥0.9 mm and NAA among controls. Mortality was associated with higher age, ischaemic ECG and NAA among patients, and cIMT ≥0.9 mm among controls. Conclusion: Atherosclerosis is highly prevalent even in young stroke patients. Some areas and increasing NAA are associated with CVEs and death. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study | |
dc.type | Journal article | |
dc.creator.author | Nawaz, Beenish | |
dc.creator.author | Fromm, Annette | |
dc.creator.author | Øygarden, Halvor | |
dc.creator.author | Eide, Geir E | |
dc.creator.author | Saeed, Sahrai | |
dc.creator.author | Meijer, Rudy | |
dc.creator.author | Bots, Michiel L | |
dc.creator.author | Sand, Kristin M | |
dc.creator.author | Thomassen, Lars | |
dc.creator.author | Næss, Halvor | |
dc.creator.author | Waje-Andreassen, Ulrike | |
cristin.unitcode | 185,0,0,0 | |
cristin.unitname | Universitetet i Oslo | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1963318 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Stroke Journal&rft.volume=6&rft.spage=374&rft.date=2021 | |
dc.identifier.jtitle | European Stroke Journal | |
dc.identifier.volume | 6 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 374 | |
dc.identifier.endpage | 384 | |
dc.identifier.doi | https://doi.org/10.1177/23969873211059472 | |
dc.identifier.urn | URN:NBN:no-92956 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2396-9873 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90363/1/23969873211059472.pdf | |
dc.type.version | PublishedVersion | |