dc.date.accessioned | 2022-01-28T19:05:42Z | |
dc.date.available | 2022-01-28T19:05:42Z | |
dc.date.created | 2021-11-01T13:11:47Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Yadav, Ajay Verhaegen, Steven Hadera, Mussie Ghezu Berntsen, Hanne Friis Berg, Vidar Lyche, Jan Ludvig Sabaredzovic, Azemira Haug, Line Småstuen Myhre, Oddvar Zimmer, Karin Elisabeth Paulsen, Ragnhild Elisabeth Ropstad, Erik Boix, Fernando . Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure. Neurotoxicology. 2021, 88, 79-87 | |
dc.identifier.uri | http://hdl.handle.net/10852/90279 | |
dc.description.abstract | Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken embryos to a POP mixture, containing 29 different compounds with concentrations based on blood levels measured in the Scandinavian human population. The mixture was injected into the allantois at embryonic day 13 (E13), aiming at a theoretical concentration of 10 times human blood levels. POPs concentrations in the brain were measured at 0.5, 1, 2, 4, 6, 24, 48, and 72 h after administration. Twenty-seven of the individual compounds were detected during at least one of the time-points analyzed. Generally, the concentrations of most of the measured compounds were within the order of magnitude of those reported in human brain samples. Differences in the speed of distribution to the brain were observed between the per- and polyfluoroalkyl substances (PFASs), which have protein binding potential, and the lipophilic polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and brominated flame retardants (BFRs). Based on pharmacokinetic modeling, PFASs were best described by a one compartment model. PFASs displayed relatively slow elimination (Kel) and persisted at high levels in the brain. Lipophilic OCPs and PCBs could be fitted to a 2-compartment model. These showed high levels in the brain relative to the dose administrated as calculated by area under the curve (AUC)/Dose. Altogether, our study showed that chicken is a suitable model to explore the distribution of POPs into the developing brain at concentrations which are relevant for humans. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure | |
dc.type | Journal article | |
dc.creator.author | Yadav, Ajay | |
dc.creator.author | Verhaegen, Steven | |
dc.creator.author | Hadera, Mussie Ghezu | |
dc.creator.author | Berntsen, Hanne Friis | |
dc.creator.author | Berg, Vidar | |
dc.creator.author | Lyche, Jan Ludvig | |
dc.creator.author | Sabaredzovic, Azemira | |
dc.creator.author | Haug, Line Småstuen | |
dc.creator.author | Myhre, Oddvar | |
dc.creator.author | Zimmer, Karin Elisabeth | |
dc.creator.author | Paulsen, Ragnhild Elisabeth | |
dc.creator.author | Ropstad, Erik | |
dc.creator.author | Boix, Fernando | |
cristin.unitcode | 185,15,23,0 | |
cristin.unitname | Farmasøytisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1950218 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurotoxicology&rft.volume=88&rft.spage=79&rft.date=2021 | |
dc.identifier.jtitle | Neurotoxicology | |
dc.identifier.volume | 88 | |
dc.identifier.startpage | 79 | |
dc.identifier.endpage | 87 | |
dc.identifier.doi | https://doi.org/10.1016/j.neuro.2021.10.013 | |
dc.identifier.urn | URN:NBN:no-92879 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0161-813X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90279/1/Yadav_2021_Per.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | EC/H2020/722634 | |