dc.date.accessioned | 2021-12-18T18:18:12Z | |
dc.date.available | 2021-12-18T18:18:12Z | |
dc.date.created | 2021-11-26T18:27:05Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Værnes, Tor Gunnar Røssberg, Jan Ivar Melle, Ingrid Nelson, Barnaby Romm, Kristin Lie Møller, Paul . Basic self-disturbance trajectories in clinical high risk for psychosis: a one-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience. 2021, 1-13 | |
dc.identifier.uri | http://hdl.handle.net/10852/89638 | |
dc.description.abstract | Abstract Basic self-disturbance (BSD) has been proposed as a driver of symptom development in schizophrenia spectrum disorders (SSDs). In a one-year follow-up of 32 patients (15–30 years) at putative risk for psychosis, we investigated trajectories of BSD levels from baseline to follow-up, and associations between clinical characteristics at baseline and follow-up, including follow-up levels of BSD (assessed with the EASE). Clinical high risk (CHR) for psychosis status and symptom severity were assessed with the SIPS/SOPS scales and also according to the cognitive basic symptoms high-risk criteria (COGDIS). DSM-IV diagnoses, functioning and other clinical characteristics were assessed with standard clinical instruments. Higher severity of negative symptoms and meeting COGDIS criteria at baseline were associated with higher BSD levels at follow-up. All measured at follow-up, higher BSD levels correlated with higher severity of positive, negative, disorganization and general symptoms, and with a lower level of global functioning. We found higher BSD levels at follow-up in subjects with schizotypal personality disorder (SPD) at baseline ( n = 5) and in SSDs at follow-up ( n = 12, including nine with SPD). Mean BSD levels decreased significantly from baseline to follow-up, but individual trajectories varied considerably. Increased BSD levels were associated with higher baseline BSD levels, non-remission of positive symptoms and functional decline. Overall, the current study indicates that subgroups in the CHR population with a higher risk of non-remission or deterioration may be identified by supplementing CHR criteria with assessment of BSD and negative symptoms. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Basic self-disturbance trajectories in clinical high risk for psychosis: a one-year follow-up study | |
dc.type | Journal article | |
dc.creator.author | Værnes, Tor Gunnar | |
dc.creator.author | Røssberg, Jan Ivar | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Nelson, Barnaby | |
dc.creator.author | Romm, Kristin Lie | |
dc.creator.author | Møller, Paul | |
cristin.unitcode | 185,53,10,14 | |
cristin.unitname | Enhet voksenpsykiatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1960026 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Archives of Psychiatry and Clinical Neuroscience&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | European Archives of Psychiatry and Clinical Neuroscience | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 13 | |
dc.identifier.doi | https://doi.org/10.1007/s00406-021-01349-6 | |
dc.identifier.urn | URN:NBN:no-92251 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0940-1334 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/89638/1/Basic%2Bself-disturbance%2Btrajectories%2Bin%2Bclinical%2Bhigh%2Brisk%2Bfor%2Bpsychosis%253B%2Ba%2Bone-year%2Bfollow-up%2Bstudy.pdf | |
dc.type.version | PublishedVersion | |