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dc.date.accessioned2021-12-15T12:07:30Z
dc.date.available2021-12-15T12:07:30Z
dc.date.created2021-06-11T12:54:20Z
dc.date.issued2021
dc.identifier.citationWestgaard, Kristine Løken Hynne, Håvard Amdal, Cecilie Delphin Young, Alix Singh, Preet Bano Chen, Xiangjun Rykke, Morten Hove, Lene Hystad Aqrawi, Lara A. Utheim, Tor Paaske Herlofson, Bente Brokstad Jensen, Janicke Liaaen . Oral and ocular late effects in head and neck cancer patients treated with radiotherapy. Scientific Reports. 2021, 11:4026, 1-11
dc.identifier.urihttp://hdl.handle.net/10852/89544
dc.description.abstractA broader understanding of oral and ocular late effects in head and neck cancer (HNC) patients who underwent intensity-modulated radiotherapy (IMRT) may provide valuable information in follow-up and improve quality of life. Twenty-nine HNC patients treated at least 6 months earlier and 30 age-matched controls were recruited. After completing several questionnaires: Oral Health Impact Profile-14 (OHIP-14), Shortened Xerostomia Inventory (SXI), Ocular Surface Disease Index (OSDI) and McMonnies Dry Eye questionnaire (MDEQ), participants underwent oral and ocular examinations. Oral examination included clinical oral dryness score (CODS) and secretion rates of unstimulated and stimulated saliva (UWS, SWS). Ocular examination included tear film break-up time, Schirmer test and ocular surface staining. The patients had more problems related to dry mouth than controls based on CODS and SXI, and more complaints of dry eye disease based on OSDI and MDEQ. UWS and SWS rates and oral health related quality of life were significantly lower in the patient group. Subjective oral dryness (SXI) correlated significantly with subjective ocular dryness (OSDI and MDEQ). Our study demonstrates that HNC patients treated with IMRT experience late effects in terms of xerostomia and ocular dryness underlining the importance of interdisciplinary approach in the evaluation and follow-up of HNC patients.
dc.languageEN
dc.publisherNature Portfolio
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleOral and ocular late effects in head and neck cancer patients treated with radiotherapy
dc.typeJournal article
dc.creator.authorWestgaard, Kristine Løken
dc.creator.authorHynne, Håvard
dc.creator.authorAmdal, Cecilie Delphin
dc.creator.authorYoung, Alix
dc.creator.authorSingh, Preet Bano
dc.creator.authorChen, Xiangjun
dc.creator.authorRykke, Morten
dc.creator.authorHove, Lene Hystad
dc.creator.authorAqrawi, Lara A.
dc.creator.authorUtheim, Tor Paaske
dc.creator.authorHerlofson, Bente Brokstad
dc.creator.authorJensen, Janicke Liaaen
cristin.unitcode185,16,17,51
cristin.unitnameOral kirurgi og oral medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1915276
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=11:4026&rft.spage=1&rft.date=2021
dc.identifier.jtitleScientific Reports
dc.identifier.volume11
dc.identifier.doihttps://doi.org/10.1038/s41598-021-83635-w
dc.identifier.urnURN:NBN:no-92165
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/89544/1/Artikkel%2B69%2BOral%2Band%2Bocular%2Blate%2Beffects%2Bin%2Bhead%2Band%2Bneck%2Bcancer%2Bpatients%2Btreated%2Bwith%2Bradiotherapy.pdf
dc.type.versionPublishedVersion
cristin.articleid4026


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