dc.date.accessioned | 2021-12-10T12:16:16Z | |
dc.date.available | 2021-12-10T12:16:16Z | |
dc.date.created | 2021-11-16T23:43:19Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Høiseth, Gudrun Hilberg, Thor Trydal, Torleif Husa, Asgeir Vindenes, Vigdis Bogstrand, Stig Tore . The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL-C. Basic & Clinical Pharmacology & Toxicology. 2021, 1-9 | |
dc.identifier.uri | http://hdl.handle.net/10852/89463 | |
dc.description.abstract | Background
The aim of this study was to evaluate the quantitative relation between common clinical chemical analyses and ethanol use, measured by a combination of the two alcohol markers phosphatidylethanol (PEth) and carbohydrate-deficient transferrin (CDT).
Methods
Results of PEth and CDT in whole blood and serum, respectively, were included, together with information on 10 different commonly measured clinical chemical analytes, as well as age and sex. PEth was analysed by UPC2-MS/MS and CDT was measured by capillary electrophoresis.
Results
Samples from 4873 patients were included. The strongest relation to alcohol consumption as measured by PEth, when correcting for age and sex, was found for HDL-C (standardized β = 0.472, p < 0.001), AST (standardized β = 0.372, p < 0.001), ferritin (standardized β = 0.332, p < 0.001) and GGT (standardized β = 0.325, p < 0.001). The relation to PEth was weak for total cholesterol, TG and ALP. No relation was found for Hb and LDL-C.
Conclusions
When using PEth as a marker for alcohol consumption, this study demonstrated the quantitative relation to commonly used test as AST or GGT, but also an important relation to ferritin or HDL-C. In clinical practice, elevated levels of these clinical chemical analytes should initiate further work-up on possibly harmful alcohol use. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL-C | |
dc.type | Journal article | |
dc.creator.author | Høiseth, Gudrun | |
dc.creator.author | Hilberg, Thor | |
dc.creator.author | Trydal, Torleif | |
dc.creator.author | Husa, Asgeir | |
dc.creator.author | Vindenes, Vigdis | |
dc.creator.author | Bogstrand, Stig Tore | |
cristin.unitcode | 185,53,10,12 | |
cristin.unitname | Senter for rus- og avhengighetsforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1955363 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Basic & Clinical Pharmacology & Toxicology&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Basic & Clinical Pharmacology & Toxicology | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 9 | |
dc.identifier.doi | https://doi.org/10.1111/bcpt.13662 | |
dc.identifier.urn | URN:NBN:no-92092 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1742-7835 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/89463/2/The%2Balcohol%2Bmarker%2Bphosphatidylethanol%2Bis%2Bclosely%2Brelated%2Bto%2BAST%252C%2BGGT%252C%2Bferritin%2Band%2BHDL-C.pdf | |
dc.type.version | PublishedVersion | |