dc.date.accessioned | 2021-11-22T16:12:51Z | |
dc.date.available | 2021-11-22T16:12:51Z | |
dc.date.created | 2021-11-10T13:32:37Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Pedersen, Kine Portnoy, Allison Sy, Stephen Hansen, Bo Terning Trope, Ameli Kim, Jane J Burger, Emily Annika . Switching clinic-based cervical cancer screening programs to human papillomavirus self-sampling: A cost-effectiveness analysis of vaccinated and unvaccinated Norwegian women. International Journal of Cancer. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/89274 | |
dc.description.abstract | Several countries have implemented primary human papillomavirus (HPV) testing for cervical cancer screening. HPV testing enables home-based, self-collected sampling (self-sampling), which provides similar diagnostic accuracy as clinician-collected samples. We evaluated the impact and cost-effectiveness of switching an entire organized screening program to primary HPV self-sampling among cohorts of HPV vaccinated and unvaccinated Norwegian women. We conducted a model-based analysis to project long-term health and economic outcomes for birth cohorts with different HPV vaccine exposure, that is, preadolescent vaccination (2000- and 2008-cohorts), multiage cohort vaccination (1991-cohort) or no vaccination (1985- cohort). We compared the cost-effectiveness of switching current guidelines with clinician-collected HPV testing to HPV self-sampling for these cohorts and considered an additional 44 strategies involving either HPV self-sampling or clinician-collected HPV testing at different screening frequencies for the 2000- and 2008-cohorts. Given Norwegian benchmarks for cost-effectiveness, we considered a strategy with an additional cost per quality-adjusted life-year below $55 000 as cost-effective. HPV selfsampling strategies considerably reduced screening costs (ie, by 24%-40% across cohorts and alternative strategies) and were more cost-effective than cliniciancollected HPV testing. For cohorts offered preadolescent vaccination, cost-effective strategies involved HPV self-sampling three times (2000-cohort) and twice (2008-cohort) per lifetime. In conclusion, we found that switching from cliniciancollected to self-collected HPV testing in cervical screening may be cost-effective among both highly vaccinated and unvaccinated cohorts of Norwegian women. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Switching clinic-based cervical cancer screening programs to human papillomavirus self-sampling: A cost-effectiveness analysis of vaccinated and unvaccinated Norwegian women | |
dc.type | Journal article | |
dc.creator.author | Pedersen, Kine | |
dc.creator.author | Portnoy, Allison | |
dc.creator.author | Sy, Stephen | |
dc.creator.author | Hansen, Bo Terning | |
dc.creator.author | Trope, Ameli | |
dc.creator.author | Kim, Jane J | |
dc.creator.author | Burger, Emily Annika | |
cristin.unitcode | 185,52,11,0 | |
cristin.unitname | Avdeling for helseledelse og helseøkonomi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1953212 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Cancer&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | International Journal of Cancer | |
dc.identifier.doi | https://doi.org/10.1002/ijc.33850 | |
dc.identifier.urn | URN:NBN:no-91892 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0020-7136 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/89274/1/Pedersen2021_SelfSamplingCEA.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | KF/198073 | |