Porphyromonas gingivalis-induced neuroinflammation in Alzheimer's disease

dc.date.accessioned	2021-10-18T15:16:00Z
dc.date.available	2021-10-18T15:16:00Z
dc.date.created	2021-10-14T09:48:10Z
dc.date.issued	2021
dc.identifier.citation	Olsen, Ingar . Porphyromonas gingivalis-induced neuroinflammation in Alzheimer's disease. Frontiers in Neuroscience. 2021, 15
dc.identifier.uri	http://hdl.handle.net/10852/88964
dc.description.abstract	“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. In addition, neuroinflammation induced by P. gingivalis has increasingly been recognized as a factor in the pathogenesis of AD. The present mini-review discusses possible mechanisms for the induction of neuroinflammation by P. gingivalis in AD, involving factors such as pro-inflammatory mediators, amyloid-beta, tau, microglia, cathepsin B, and protein kinase R. Inflammagens of P. gingivalis such as lipopolysaccharide and gingipains are also discussed.
dc.language	EN
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.title	Porphyromonas gingivalis-induced neuroinflammation in Alzheimer's disease
dc.type	Journal article
dc.creator.author	Olsen, Ingar
cristin.unitcode	185,16,15,0
cristin.unitname	Institutt for oral biologi
cristin.ispublished	true
cristin.fulltext	original
cristin.qualitycode	1
dc.identifier.cristin	1945826
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Neuroscience&rft.volume=15&rft.spage=&rft.date=2021
dc.identifier.jtitle	Frontiers in Neuroscience
dc.identifier.volume	15
dc.identifier.doi	https://doi.org/10.3389/fnins.2021.691016
dc.identifier.urn	URN:NBN:no-91576
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	1662-4548
dc.identifier.fulltext	Fulltext https://www.duo.uio.no/bitstream/handle/10852/88964/4/fnins-15-691016.pdf
dc.type.version	PublishedVersion
cristin.articleid	69116