dc.date.accessioned | 2021-09-30T15:32:02Z | |
dc.date.available | 2021-09-30T15:32:02Z | |
dc.date.created | 2021-09-06T12:49:45Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Yuan, Xiuxia Wang, Yunpeng Li, Xue Jiang, Jiajun Kang, Yulin Pang, Lijuan Zhang, Peifen Lv, Luxian Andreassen, Ole A Hu, Shaohua Song, Xueqin . Gut Microbial Biomarkers for the Treatment Efficacy of the First Episode, Drug-free Schizophrenia: A 24-week Follow-up Study of Antipsychotic treatment. Translational Psychiatry. 2021, 11(1), 1-9 | |
dc.identifier.uri | http://hdl.handle.net/10852/88681 | |
dc.description.abstract | Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via the gut-brain axis. However, its role in the antipsychotic treatment response is unclear. Here, we present a 24-week follow-up study to identify gut microbial biomarkers for SCH diagnosis and treatment response, using a sample of 107 first-episode, drug-naïve SCH patients, and 107 healthy controls (HCs). We collected biological samples at baseline (all participants) and follow-up time points after risperidone treatment (SCH patients). Treatment response was assessed using the Positive and Negative Symptoms Scale total (PANSS-T) score. False discovery rate was used to correct for multiple testing. We found that SCH patients showed lower α-diversity (the Shannon and Simpson’s indices) compared to HCs at baseline (p = 1.21 × 10−9, 1.23 × 10−8, respectively). We also found a significant difference in β-diversity between SCH patients and HCs (p = 0.001). At baseline, using microbes that showed different abundance between patients and controls as predictors, a prediction model can distinguish patients from HCs with an area under the curve (AUC) of 0.867. In SCH patients, after 24 weeks of risperidone treatment, we observed an increase of α-diversity toward the basal level of HCs. At the genus level, we observed decreased abundance of Lachnoclostridium (p = 0.019) and increased abundance Romboutsia (p = 0.067). Moreover, the treatment response in SCH patients was significantly associated with the basal levels of Lachnoclostridium and Romboutsia (p = 0.005 and 0.006, respectively). Our results suggest that SCH patients may present characteristic microbiota, and certain microbiota biomarkers may predict treatment response in this patient population. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Gut Microbial Biomarkers for the Treatment Efficacy of the First Episode, Drug-free Schizophrenia: A 24-week Follow-up Study of Antipsychotic treatment | |
dc.type | Journal article | |
dc.creator.author | Yuan, Xiuxia | |
dc.creator.author | Wang, Yunpeng | |
dc.creator.author | Li, Xue | |
dc.creator.author | Jiang, Jiajun | |
dc.creator.author | Kang, Yulin | |
dc.creator.author | Pang, Lijuan | |
dc.creator.author | Zhang, Peifen | |
dc.creator.author | Lv, Luxian | |
dc.creator.author | Andreassen, Ole A | |
dc.creator.author | Hu, Shaohua | |
dc.creator.author | Song, Xueqin | |
cristin.unitcode | 185,17,5,0 | |
cristin.unitname | Psykologisk institutt | |
cristin.ispublished | false | |
cristin.fulltext | preprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1931606 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational Psychiatry&rft.volume=11&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Translational Psychiatry | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41398-021-01531-3 | |
dc.identifier.urn | URN:NBN:no-91300 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2158-3188 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/88681/2/s41398-021-01531-3.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 422 | |
dc.relation.project | NFR/302854 | |
dc.relation.project | NFR/223273 | |
dc.relation.project | UIO/UiO:Life Science Convergence Environment (4MENT) | |