dc.date.accessioned | 2021-08-08T15:35:26Z | |
dc.date.available | 2021-08-08T15:35:26Z | |
dc.date.created | 2021-07-12T08:21:21Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Jørgensen, Hanne Eide, Ivar Anders Jenssen, Trond Geir Åsberg, Anders Bollerslev, Jens Godang, Kristin Hartmann, Anders Schmidt, Erik Berg Svensson, My Hanna Sofia . Marine n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Kidney Transplant Recipients: A Randomized, Placebo-Controlled Trial. Nutrients. 2021, 13(7) | |
dc.identifier.uri | http://hdl.handle.net/10852/86714 | |
dc.description.abstract | Kidney transplant recipients are at high risk of progressive bone loss and low-energy fractures in the years following transplantation. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation may have beneficial effects on bone strength. The Omega-3 fatty acids in Renal Transplantation (ORENTRA) trial was an investigator initiated, randomized, placebo-controlled trial investigating the effects of marine n-3 PUFA supplementation after kidney transplantation. Effects of supplementation on bone mineral density (BMD) and calcium metabolism were pre-defined secondary endpoints. Adult kidney transplant recipients (n = 132) were randomized to 2.6 g marine n-3 PUFA supplement or olive oil (control) from 8 to 52 weeks post-transplant. Dual energy X-ray absorptiometry was performed to assess changes in bone mineral density of hip, spine, and forearm, as well as trabecular bone score (TBS) of the lumbar spine. Student’s t test was used to assess between-group differences. There were no differences in ΔBMD between the two groups (intervention vs. control) at lumbar spine (−0.020 ± 0.08 vs. −0.007 ± 0.07 g/cm², p = 0.34), total hip (0.001 ± 0.03 vs. −0.005 ± 0.04, p = 0.38), or other skeletal sites in the intention-to-treat analyses. There was no difference in the change in TBS score (0.001 ± 0.096 vs. 0.009 ± 0.102, p = 0.62). Finally, no effect on biochemical parameters of mineral metabolism was seen. Results were similar when analyzed per protocol. In conclusion, we found no significant effect of 44 weeks of supplementation with 2.6 g of marine n-3 PUFA on BMD in kidney transplant recipients. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Marine n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Kidney Transplant Recipients: A Randomized, Placebo-Controlled Trial | |
dc.type | Journal article | |
dc.creator.author | Jørgensen, Hanne | |
dc.creator.author | Eide, Ivar Anders | |
dc.creator.author | Jenssen, Trond Geir | |
dc.creator.author | Åsberg, Anders | |
dc.creator.author | Bollerslev, Jens | |
dc.creator.author | Godang, Kristin | |
dc.creator.author | Hartmann, Anders | |
dc.creator.author | Schmidt, Erik Berg | |
dc.creator.author | Svensson, My Hanna Sofia | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1921404 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.volume=13&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Nutrients | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 7 | |
dc.identifier.pagecount | 10 | |
dc.identifier.doi | https://doi.org/10.3390/nu13072361 | |
dc.identifier.urn | URN:NBN:no-89353 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2072-6643 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/86714/1/nutrients-13-02361-v3.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 2361 | |