| dc.description.abstract | Objective: This project thesis aims to investigate the mechanisms, clinical impacts, and side effects related to Nonsteroidal anti-inflammatory drugs (NSAIDs) and relate this to the extensive use of NSAIDs among athletes. Methods: Literature study. Results: NSAIDs exert their analgesic and anti-inflammatory effects through inhibition of the cyclooxygenase (COX)-isoenzymes, thus reducing prostaglandin production. There are uncertainties concerning the long-term effects of NSAIDs on the recovery of musculoskeletal injuries. All NSAIDs increase the risk of adverse effects affecting the cardiovascular system, the kidneys, and the gastrointestinal tract. Individuals with underlying risk factors or chronic diseases are particularly at risk for developing NSAID-induced side effects, but healthy people can also be affected. Consumption of NSAIDs among both elite athletes and amateurs in different kinds of sports is frequent. Simultaneously, there is a lack of knowledge concerning NSAIDs and adverse effects among athletes. Common causes for usage are pain relief, enhanced injury recovery, and prophylaxis against pain and injury. The combination of NSAIDs and intense exercise can cause increased risk of damage to the mucosal membrane of the gastrointestinal tract, and increased risk of renal impairment. Intense exercise and intake of NSAIDs may increase the risk of cardiovascular events. Conclusion: NSAIDs can lead to cardiovascular, gastrointestinal and renal adverse effects, which may be potentiated by exercise. The consumption of NSAIDs among athletes is high, and they have limited knowledge regarding potential side effects. More research about adverse effects of NSAIDs among athletes is needed. Athletes should receive more information about NSAIDs. | eng |