dc.date.accessioned | 2021-04-29T20:13:12Z | |
dc.date.available | 2021-04-29T20:13:12Z | |
dc.date.created | 2021-03-19T17:16:49Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Becker-Bense, Sandra Willoch, Frode Stephan, Thomas Brendel, M. Yakushev, Igor Habs, Maximilian Ziegler, Sibylle Herz, Michael Schwaiger, Markus Dieterich, Marianne Bartenstein, Peter . Direct comparison of activation maps during galvanic vestibular stimulation: A hybrid H2[15 O] PET—BOLD MRI activation study. PLOS ONE. 2020, 15(5) | |
dc.identifier.uri | http://hdl.handle.net/10852/85754 | |
dc.description.abstract | Previous unimodal PET and fMRI studies in humans revealed a reproducible vestibular brain activation pattern, but with variations in its weighting and expansiveness. Hybrid studies minimizing methodological variations at baseline conditions are rare and still lacking for task-based designs. Thus, we applied for the first time hybrid 3T PET-MRI scanning (Siemens mMR) in healthy volunteers using galvanic vestibular stimulation (GVS) in healthy volunteers in order to directly compare H215O-PET and BOLD MRI responses. List mode PET acquisition started with the injection of 750 MBq H215O simultaneously to MRI EPI sequences. Group-level statistical parametric maps were generated for GVS vs. rest contrasts of PET, MR-onset (event-related), and MR-block. All contrasts showed a similar bilateral vestibular activation pattern with remarkable proximity of activation foci. Both BOLD contrasts gave more bilateral wide-spread activation clusters than PET; no area showed contradictory signal responses. PET still confirmed the right-hemispheric lateralization of the vestibular system, whereas BOLD-onset revealed only a tendency. The reciprocal inhibitory visual-vestibular interaction concept was confirmed by PET signal decreases in primary and secondary visual cortices, and BOLD-block decreases in secondary visual areas. In conclusion, MRI activation maps contained a mixture of CBF measured using H215O-PET and additional non-CBF effects, and the activation-deactivation pattern of the BOLD-block appears to be more similar to the H215O-PET than the BOLD-onset. | |
dc.language | EN | |
dc.publisher | PLOS | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Direct comparison of activation maps during galvanic vestibular stimulation: A hybrid H2[15 O] PET—BOLD MRI activation study | |
dc.type | Journal article | |
dc.creator.author | Becker-Bense, Sandra | |
dc.creator.author | Willoch, Frode | |
dc.creator.author | Stephan, Thomas | |
dc.creator.author | Brendel, M. | |
dc.creator.author | Yakushev, Igor | |
dc.creator.author | Habs, Maximilian | |
dc.creator.author | Ziegler, Sibylle | |
dc.creator.author | Herz, Michael | |
dc.creator.author | Schwaiger, Markus | |
dc.creator.author | Dieterich, Marianne | |
dc.creator.author | Bartenstein, Peter | |
cristin.unitcode | 185,51,12,34 | |
cristin.unitname | Nevrale systemer | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1899512 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=15&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | PLOS ONE | |
dc.identifier.volume | 15 | |
dc.identifier.issue | 5 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0233262 | |
dc.identifier.urn | URN:NBN:no-88413 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85754/2/pone.0233262.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0233262 | |