dc.date.accessioned | 2021-04-24T19:47:50Z | |
dc.date.available | 2021-04-24T19:47:50Z | |
dc.date.created | 2021-02-08T11:52:38Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Juvodden, Hilde Therese Viken, Marte Kathrine Nordstrand, Sebjørg Elizabeth Hesla Viste, Rannveig Westlye, Lars Tjelta Thorsby, Per Medbøe Lie, Benedicte Alexandra Knudsen, Stine . HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives. Sleep. 2020, 43(3), 1-11 | |
dc.identifier.uri | http://hdl.handle.net/10852/85569 | |
dc.description.abstract | Abstract
Study Objectives
To explore HLA (human leukocyte antigen) in post-H1N1 narcolepsy type 1 patients (NT1), first-degree relatives and healthy controls, and assess HLA associations with clinical and sleep parameters in patients and first-degree relatives.
Methods
Ninety post-H1N1 NT1 patients and 202 of their first-degree relatives were HLA-genotyped (next generation sequencing) and phenotyped (semistructured interviews, Stanford Sleep Questionnaire, polysomnography, and multiple sleep latency test). HLA allele distributions were compared between DQB1*06:02-heterozygous individuals (77 patients, 59 parents, 1230 controls). A subsample (74 patients, 114 relatives) was investigated for associations between HLA-loci and continuous sleep variables using logistic regression. Identified candidate HLA-loci were explored for HLA allele associations with hypnagogic hallucinations and sleep paralysis in 90 patients, and patient allele findings were checked for similar associations in 202 relatives.
Results
DQB1*06:02 heterozygous post-H1N1 NT1 patients (84.4% H1N1-vaccinated) showed several significant HLA associations similar to those reported previously in samples of mainly sporadic NT1, i.e. DQB1*03:01, DRB1*04:01, DRB1*04:02, DRB1*04:07, DRB1*11:04, A*25:01, B*35:03, and B*51:01, and novel associations, i.e. B*14:02, C*01:02, and C*07:01. Parents HLA alleles did not deviate significantly from controls. The HLA-C locus was associated with sleep parameters in patients and relatives. In patients C*02:02 seems to be associated with protective effects against sleep paralysis and hypnagogic hallucinations.
Conclusions
Our findings of similar risk/protective HLA-alleles in post-H1N1 as in previous studies of mainly sporadic narcolepsy support similar disease mechanisms. We also report novel allelic associations. Associations between HLA-C and sleep parameters were seen independent of NT1 diagnosis, supporting involvement of HLA-C in sleep subphenotypes. | |
dc.language | EN | |
dc.title | HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives | |
dc.type | Journal article | |
dc.creator.author | Juvodden, Hilde Therese | |
dc.creator.author | Viken, Marte Kathrine | |
dc.creator.author | Nordstrand, Sebjørg Elizabeth Hesla | |
dc.creator.author | Viste, Rannveig | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Thorsby, Per Medbøe | |
dc.creator.author | Lie, Benedicte Alexandra | |
dc.creator.author | Knudsen, Stine | |
cristin.unitcode | 185,53,42,13 | |
cristin.unitname | Nevrologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1887580 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Sleep&rft.volume=43&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | Sleep | |
dc.identifier.volume | 43 | |
dc.identifier.issue | 3 | |
dc.identifier.doi | https://doi.org/10.1093/sleep/zsz239 | |
dc.identifier.urn | URN:NBN:no-88240 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0161-8105 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85569/1/HLA%2Band%2Bsleep%2Bparameter%2Bassociations%2Bin%2Bpost-H1N1%2Bnarcolepsy%2Btype%2B1%2Bpatients%2Band%2Bfirst-degree%2Brelatives.pdf | |
dc.type.version | AcceptedVersion | |
cristin.articleid | zsz239 | |