dc.date.accessioned | 2021-04-23T19:35:34Z | |
dc.date.available | 2021-04-23T19:35:34Z | |
dc.date.created | 2021-02-23T18:05:57Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Pérez, Laura M. Hooshmand, Babak Mangialasche, Francesca Mecocci, Patrizia Smith, A David Refsum, Helga Inzitari, Marco Fratiglioni, Laura Rizzuto, Debora Calderón-Larrañaga, Amaia . Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 2020, 75(6), 1089-1094 | |
dc.identifier.uri | http://hdl.handle.net/10852/85508 | |
dc.description.abstract | Abstract
We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3.3 vs 3.6 µmol/L; p < .001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: −0.044, p < .001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults | |
dc.type | Journal article | |
dc.creator.author | Pérez, Laura M. | |
dc.creator.author | Hooshmand, Babak | |
dc.creator.author | Mangialasche, Francesca | |
dc.creator.author | Mecocci, Patrizia | |
dc.creator.author | Smith, A David | |
dc.creator.author | Refsum, Helga | |
dc.creator.author | Inzitari, Marco | |
dc.creator.author | Fratiglioni, Laura | |
dc.creator.author | Rizzuto, Debora | |
dc.creator.author | Calderón-Larrañaga, Amaia | |
cristin.unitcode | 185,51,13,41 | |
cristin.unitname | Molekylær ernæringsbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1892906 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The journals of gerontology. Series A, Biological sciences and medical sciences&rft.volume=75&rft.spage=1089&rft.date=2020 | |
dc.identifier.jtitle | The journals of gerontology. Series A, Biological sciences and medical sciences | |
dc.identifier.volume | 75 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 1089 | |
dc.identifier.endpage | 1094 | |
dc.identifier.doi | https://doi.org/10.1093/gerona/glz101 | |
dc.identifier.urn | URN:NBN:no-88176 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1079-5006 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85508/2/1892906%2B-%2BHelga%2BRefsum.pdf | |
dc.type.version | PublishedVersion | |