dc.date.accessioned | 2021-04-21T19:23:57Z | |
dc.date.available | 2021-04-21T19:23:57Z | |
dc.date.created | 2021-01-13T20:13:49Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gorbach, Tetiana Pudas, Sara Bartrés-Faz, David Brandmaier, Andreas M. Düzel, Sandra Henson, Rik Idland, Ane-Victoria Lindenberger, Ulman Macià Bros, Didac Mowinckel, Athanasia Monika Solé-Padullés, Cristina Sørensen, Øystein Walhovd, Kristine B Watne, Leiv Otto Westerhausen, Rene Fjell, Anders Martin Nyberg, Lars Erik . Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/85419 | |
dc.description.abstract | Introduction The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic‐memory decline in non‐demented individuals remains unclear. Methods We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium. Results The change‐change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non‐carriers: N = 467, r = 0.073, P = .117). The linear relationship was significantly steeper for the carriers [t(629) = 2.4, P = .013]. A similar trend toward a stronger change‐change relation for carriers was seen in a subsample with more than two assessments. Discussion These findings provide evidence for a difference in hippocampus‐memory association between ε4 carriers and non‐carriers, thus highlighting how genetic factors modulate the translation of the AD‐related pathophysiological cascade into cognitive deficits. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers | |
dc.type | Journal article | |
dc.creator.author | Gorbach, Tetiana | |
dc.creator.author | Pudas, Sara | |
dc.creator.author | Bartrés-Faz, David | |
dc.creator.author | Brandmaier, Andreas M. | |
dc.creator.author | Düzel, Sandra | |
dc.creator.author | Henson, Rik | |
dc.creator.author | Idland, Ane-Victoria | |
dc.creator.author | Lindenberger, Ulman | |
dc.creator.author | Macià Bros, Didac | |
dc.creator.author | Mowinckel, Athanasia Monika | |
dc.creator.author | Solé-Padullés, Cristina | |
dc.creator.author | Sørensen, Øystein | |
dc.creator.author | Walhovd, Kristine B | |
dc.creator.author | Watne, Leiv Otto | |
dc.creator.author | Westerhausen, Rene | |
dc.creator.author | Fjell, Anders Martin | |
dc.creator.author | Nyberg, Lars Erik | |
cristin.unitcode | 185,53,11,15 | |
cristin.unitname | Geriatrisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1870937 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1002/dad2.12110 | |
dc.identifier.urn | URN:NBN:no-88114 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2352-8729 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85419/2/Gorbach%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NOTUR/NORSTORE/NS9084S | |
dc.relation.project | NOTUR/NORSTORE/NS9737S | |
dc.relation.project | NFR/249931 | |
dc.relation.project | ERC/313440 | |
dc.relation.project | ERC/283634 | |
dc.relation.project | ERC/725025 | |
dc.relation.project | EC/H2020/732592 | |