dc.date.accessioned | 2021-04-20T20:27:29Z | |
dc.date.available | 2021-04-20T20:27:29Z | |
dc.date.created | 2021-02-21T13:27:33Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Purple, R.J. Cosgrave, J. Vyazovskiy, V. Foster, R.G. Porcheret, Kate Louise Wulff, K. . Sleep-related memory consolidation in the psychosis spectrum phenotype. Neurobiology of Learning and Memory. 2020, 174 | |
dc.identifier.uri | http://hdl.handle.net/10852/85413 | |
dc.description.abstract | Sleep and memory processing impairments range from mild to severe in the psychosis spectrum. Relationships between memory processing and sleep characteristics have been described for schizophrenia, including unaffected first-degree relatives, but they are less clear across other high-risk groups within the psychosis spectrum. In this study, we investigated high-risk individuals with accumulated risk-factors for psychosis and subthreshold symptoms. Out of 1898 screened individuals, 44 age- and sex-matched participants were sub-grouped into those with substantial environmental risk factors for psychosis and subthreshold psychotic symptoms (high-risk group) and those without these phenotypes (low-risk controls). Four groups (high/low risk, morning/evening training) were trained and tested in the laboratory for sustained attention, motor skill memory (finger-tapping task) and declarative memory (word-pair learning task) immediately after training, again after a night of EEG-recorded sleep at home or a period of daytime wakefulness, and again after 24 h from training. No differences in sustained attention or in memory consolidation of declarative and motor skill memory were found between groups for any time period tested. However, a group difference was found for rapid-eye movement (REM) sleep in relation to motor skill memory: the longer the total sleep time, particularly longer REM sleep, the greater the performance gain, which occurred only in high-risk individuals. In conclusion, our results suggest a gain in motor skill performance with sufficient sleep opportunity for longer REM sleep in high-risk individuals with subthreshold psychotic symptoms. Declarative memory did not benefit from sleep consolidation above or beyond that of the control group. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Sleep-related memory consolidation in the psychosis spectrum phenotype | |
dc.type | Journal article | |
dc.creator.author | Purple, R.J. | |
dc.creator.author | Cosgrave, J. | |
dc.creator.author | Vyazovskiy, V. | |
dc.creator.author | Foster, R.G. | |
dc.creator.author | Porcheret, Kate Louise | |
dc.creator.author | Wulff, K. | |
cristin.unitcode | 185,53,0,0 | |
cristin.unitname | Institutt for klinisk medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1892092 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurobiology of Learning and Memory&rft.volume=174&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Neurobiology of Learning and Memory | |
dc.identifier.volume | 174 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1016/j.nlm.2020.107273 | |
dc.identifier.urn | URN:NBN:no-88083 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1074-7427 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85413/1/Sleep-related%2Bmemory%2Bconsolidation%2Bin%2Bthe%2Bpsychosis%2Bspectrum%2Bphenotype.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 107273 | |