dc.date.accessioned | 2021-04-20T19:24:04Z | |
dc.date.available | 2021-04-20T19:24:04Z | |
dc.date.created | 2021-02-15T19:07:28Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gul, Kiran Aftab Strand, Janne Maren Pettersen, Rolf Dagfinn Brun, Henrik Abrahamsen, Tore G . T-cell Receptor Excision Circles in Newborns with Heart Defects. Pediatric Cardiology. 2020, 41(4), 809-815 | |
dc.identifier.uri | http://hdl.handle.net/10852/85384 | |
dc.description.abstract | Abstract In the fetus, the cardiac neural crest gives rise to both the thymus and the conotruncus of the heart. In newborn screening for severe T-cell lymphopenia neonates with congenital heart defects may be detected. In this study, we investigated the occurrence of T-cell lymphopenia in neonates with or without 22q11.2 deletion syndrome (del) suffering from heart defects. This retrospective cohort study included 125 patients with heart defects. T-cell receptor excision circles (TRECs), a measure for T-cell lymphopenia, were quantified by RT-PCR using stored newborn screening blood spots. Three patient groups were compared: non-conotruncal defects ( n = 57), conotruncal defects ( n = 42), and 22q11.2 del with conotruncal defects ( n = 26). Significantly lower TREC values were detected in patients with 22q11.2 del and conotruncal heart defects compared to those with non-syndromic conotruncal ( p < 0.001) and non-conotruncal ( p < 0.001) defects. In contrast, no significant difference was found between patients with non-syndromic conotruncal and non-conotruncal heart defects ( p = 0.152). Low TREC levels were obtained in neonates treated with heart surgery/intervention within 2 weeks after birth and in those with a fatal outcome ( p = 0.02) independent of patient group. A correlation was found between low TREC numbers and oxygen saturation, SpO 2 below 95% ( p = 0.017). The SpO 2 was significantly lower in the non-syndromic conotruncal group compared to non-conotruncal ( p < 0.001) and 22q11.2 del group ( p = 0.015). No correlation was found between low neonatal TRECs and infections needing hospitalization later in life ( p = 0.135). Patients with 22q11.2 del and conotruncal defects have significantly lower TREC levels compared to patients with heart defects without this syndrome. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | T-cell Receptor Excision Circles in Newborns with Heart Defects | |
dc.type | Journal article | |
dc.creator.author | Gul, Kiran Aftab | |
dc.creator.author | Strand, Janne Maren | |
dc.creator.author | Pettersen, Rolf Dagfinn | |
dc.creator.author | Brun, Henrik | |
dc.creator.author | Abrahamsen, Tore G | |
cristin.unitcode | 185,53,46,10 | |
cristin.unitname | Pediatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1890114 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pediatric Cardiology&rft.volume=41&rft.spage=809&rft.date=2020 | |
dc.identifier.jtitle | Pediatric Cardiology | |
dc.identifier.volume | 41 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 809 | |
dc.identifier.endpage | 815 | |
dc.identifier.doi | https://doi.org/10.1007/s00246-020-02317-y | |
dc.identifier.urn | URN:NBN:no-88062 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0172-0643 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85384/1/Gul2020_Article_T-cellReceptorExcisionCirclesI.pdf | |
dc.type.version | PublishedVersion | |