dc.date.accessioned | 2021-04-14T20:07:23Z | |
dc.date.available | 2021-04-14T20:07:23Z | |
dc.date.created | 2021-02-17T13:19:07Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Lyngbakken, Magnus Kvisvik, Brede Alexander Aagaard, Erika Nerdrum Berge, Trygve Pervez, Mohammad Osman Brynildsen, Jon Tveit, Arnljot Steine, Kjetil Røsjø, Helge Omland, Torbjørn . B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healtahy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clinical Chemistry. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/85259 | |
dc.description.abstract | Abstract
Background
Concentrations of B-type natriuretic peptide (BNP) reflect myocardial distension and stress, and are associated with poor prognosis in patients with cardiovascular disease. Accordingly, we hypothesized that concentrations of BNP would be associated with indices of adverse left ventricular (LV) remodeling and early stages of LV systolic and diastolic dysfunction in healthy participants from the general population.
Methods
We measured BNP in 1757 women and 1677 men free from known coronary heart disease participating in the prospective observational Akershus Cardiac Examination 1950 Study. All study participants underwent extensive cardiovascular phenotyping at baseline, including detailed echocardiography with assessment of indexed LV mass (LVMI), diastolic [tissue Doppler e’, E/e’ ratio, indexed left atrial volume (LAVI), maximal tricuspid regurgitation velocity (TRVmax), and E/A ratio], and systolic [global longitudinal strain (GLS) and LV ejection fraction (LVEF)] function.
Results
Study participants with the highest BNP concentrations had higher GLS, LVMI, e’, E/e’ ratio, LAVI, TRVmax, and E/A ratio. In adjusted analyses, both GLS and LVEF exhibited significant nonlinear associations with BNP, with reduced LV systolic function observed in both the low and high concentration range of BNP.
Conclusions
In healthy participants recruited from the general population, concentrations of BNP exhibit nonlinear associations with LV systolic function, and both low and high concentrations are associated with reduced LV systolic function. This supports the notion that natriuretic peptides are beneficial and elicit cardioprotective effects, and may have important implications for the interpretation of BNP measurements in the general population. | |
dc.language | EN | |
dc.publisher | American Association for Clinical Chemistry | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healtahy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study | |
dc.type | Journal article | |
dc.creator.author | Lyngbakken, Magnus | |
dc.creator.author | Kvisvik, Brede Alexander | |
dc.creator.author | Aagaard, Erika Nerdrum | |
dc.creator.author | Berge, Trygve | |
dc.creator.author | Pervez, Mohammad Osman | |
dc.creator.author | Brynildsen, Jon | |
dc.creator.author | Tveit, Arnljot | |
dc.creator.author | Steine, Kjetil | |
dc.creator.author | Røsjø, Helge | |
dc.creator.author | Omland, Torbjørn | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1890894 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical Chemistry&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Clinical Chemistry | |
dc.identifier.volume | 67 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 204 | |
dc.identifier.endpage | 215 | |
dc.identifier.doi | https://doi.org/10.1093/clinchem/hvaa257 | |
dc.identifier.urn | URN:NBN:no-87869 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0009-9147 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85259/1/hvaa257.pdf | |
dc.type.version | PublishedVersion | |