dc.date.accessioned | 2021-03-26T18:48:58Z | |
dc.date.available | 2021-03-26T18:48:58Z | |
dc.date.created | 2020-12-29T12:28:31Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Berge, Kristian Lyngbakken, Magnus Myhre, Peder Langeland Brynildsen, Jon Røysland, Ragnhild Strand, Heidi Christensen, Geir Arve Høiseth, Arne Didrik Omland, Torbjørn Røsjø, Helge . High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study. Clinical Biochemistry. 2020, 1-7 | |
dc.identifier.uri | http://hdl.handle.net/10852/84928 | |
dc.description.abstract | Background
To assess if cardiac troponins can improve diagnostics of acute heart failure (AHF) and provide prognostic information in patients with acute dyspnea.
Methods
We measured cardiac troponin T with a high-sensitivity assay (hs-cTnT) in 314 patients hospitalized with acute dyspnea. The index diagnosis was adjudicated and AHF patients were stratified into AHF with reduced or preserved ejection fraction (HFrEF/HFpEF). The prognostic and diagnostic merit of hs-cTnT was compared to the merit of N-terminal pro-B-type natriuretic peptide (NT-proBNP).
Results
In the total population, median age was 73 (quartile [Q] 1–3 63–81) years and 48% were women. One-hundred-forty-three patients were categorized as AHF (46%) and these patients had higher hs-cTnT concentrations than patients with non-AHF-related dyspnea: median 38 (Q1-3 22–75) vs. 13 (4–25) ng/L; p < 0.001. hs-cTnT concentrations were similar between patients with HFrEF and HFpEF (p = 0.80), in contrast to NT-proBNP, which was higher in HFrEF (p < 0.001). C-statistics for discriminating HFpEF from non-AHF-related dyspnea was 0.80 (95% CI 0.73–0.86) for hs-cTnT, 0.79 (0.73–0.86) for NT–proBNP, and 0.83 (0.76–0.89) for hs-cTnT and NT-proBNP in combination. Elevated hs-cTnT remained associated with HFpEF in logistic regression analysis after adjusting for demographics, comorbidities and renal function. During median 27 months of follow-up, 114 (36%) patients died in the total population. Higher hs-cTnT concentrations were associated with increased risk of all-cause mortality after adjustment for clinical variables and NT-proBNP: hazard ratio 1.30 (95% CI 1.07–1.58), p = 0.009.
Conclusion
hs-cTnT measurements improve diagnostic accuracy for HFpEF and provide independent prognostic information in unselected patients with acute dyspnea. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study | |
dc.type | Journal article | |
dc.creator.author | Berge, Kristian | |
dc.creator.author | Lyngbakken, Magnus | |
dc.creator.author | Myhre, Peder Langeland | |
dc.creator.author | Brynildsen, Jon | |
dc.creator.author | Røysland, Ragnhild | |
dc.creator.author | Strand, Heidi | |
dc.creator.author | Christensen, Geir Arve | |
dc.creator.author | Høiseth, Arne Didrik | |
dc.creator.author | Omland, Torbjørn | |
dc.creator.author | Røsjø, Helge | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1863763 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical Biochemistry&rft.volume=&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | Clinical Biochemistry | |
dc.identifier.volume | 88 | |
dc.identifier.startpage | 30 | |
dc.identifier.endpage | 36 | |
dc.identifier.doi | https://doi.org/10.1016/j.clinbiochem.2020.11.009 | |
dc.identifier.urn | URN:NBN:no-87621 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0009-9120 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/84928/2/1-s2.0-S0009912020308869-main.pdf | |
dc.type.version | PublishedVersion | |