dc.date.accessioned | 2021-03-24T20:42:10Z | |
dc.date.available | 2021-03-24T20:42:10Z | |
dc.date.created | 2020-08-04T13:34:08Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Ejigu, Yohannes Magnus, Jeanette H. Sundby, Johanne Magnus, Maria Christine . Differences in Growth of HIV-exposed Uninfected Infants in Ethiopia According to Timing of In-utero Antiretroviral Therapy Exposure. The Pediatric Infectious Disease Journal. 2020, 39(8), 730-736 | |
dc.identifier.uri | http://hdl.handle.net/10852/84726 | |
dc.description.abstract | Background:
There are concerns about the adverse effect of in-utero exposure to antiretroviral therapy (ART) on the growth of HIV exposed-uninfected (HEU) infants. We compared growth of HEU-infants according to the timing and type of ART exposure.
Methods:
A retrospective cohort study was conducted by abstracting clinical data from HIV-infected mothers and HEU-infants in Addis Ababa, Ethiopia between February 2013 and October 2016. Mixed-effects linear models were used to compare changes in weight and length and cox proportional hazard models were used to evaluate stunting (length-for-age z score <−2.0) and underweight (weight-for-age z score <−2.0).
Results:
A total of 624 HEU-infants were included in the analyses. Infants exposed to ART from conception had a lower rate of change in length [β = −0.54, 95% confidence interval (CI): −1.00 to −0.08] the first 3 months of life, as compared with infants exposed from late pregnancy. Risk of stunting was 51.9 per 100 person-years and risk of underweight was 26.7 per 100 person-years. Exposure to ART from conception was associated with a higher rate of stunting as compared with exposure from late pregnancy (adjusted hazard ratio = 1.95, 95% CI: 1.27–2.99). Infants born to mothers with advanced disease had a higher incidence of underweight compared with infants born to mothers with early-stage disease adjusted hazard ratio = 1.99, 95% CI: 1.32–3.03).
Conclusions:
In HEU-infants, exposure to ART from conception was associated with decrease growth during early infancy and higher incidence of stunting compared with treatment exposure later in pregnancy. Close monitoring of HEU-infants’ growth and prompt nutritional intervention is essential. | |
dc.language | EN | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Differences in Growth of HIV-exposed Uninfected Infants in Ethiopia According to Timing of In-utero Antiretroviral Therapy Exposure | |
dc.type | Journal article | |
dc.creator.author | Ejigu, Yohannes | |
dc.creator.author | Magnus, Jeanette H. | |
dc.creator.author | Sundby, Johanne | |
dc.creator.author | Magnus, Maria Christine | |
cristin.unitcode | 185,0,0,0 | |
cristin.unitname | Universitetet i Oslo | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1821592 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The Pediatric Infectious Disease Journal&rft.volume=39&rft.spage=730&rft.date=2020 | |
dc.identifier.jtitle | The Pediatric Infectious Disease Journal | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 730 | |
dc.identifier.endpage | 736 | |
dc.identifier.doi | https://doi.org/10.1097/INF.0000000000002678 | |
dc.identifier.urn | URN:NBN:no-87430 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0891-3668 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/84726/2/Ejigu_2020_Dif.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/262700 | |