Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts

dc.date.accessioned	2021-03-15T19:58:43Z
dc.date.available	2021-03-15T19:58:43Z
dc.date.created	2020-11-24T14:50:48Z
dc.date.issued	2020
dc.identifier.citation	Berntsen, Linn Neerbye Nova, Ainara Wragg, David Sandtorv, Alexander Harald . Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts. Organic Letters. 2020, 22(7), 2687-2691
dc.identifier.uri	http://hdl.handle.net/10852/84087
dc.description.abstract	A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.
dc.language	EN
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.title	Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
dc.type	Journal article
dc.creator.author	Berntsen, Linn Neerbye
dc.creator.author	Nova, Ainara
dc.creator.author	Wragg, David
dc.creator.author	Sandtorv, Alexander Harald
cristin.unitcode	185,15,12,57
cristin.unitname	Organisk kjemi
cristin.ispublished	true
cristin.fulltext	original
cristin.qualitycode	2
dc.identifier.cristin	1851762
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Organic Letters&rft.volume=22&rft.spage=2687&rft.date=2020
dc.identifier.jtitle	Organic Letters
dc.identifier.volume	22
dc.identifier.issue	7
dc.identifier.startpage	2687
dc.identifier.endpage	2691
dc.identifier.doi	https://doi.org/10.1021/acs.orglett.0c00642
dc.identifier.urn	URN:NBN:no-86815
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	1523-7060
dc.identifier.fulltext	Fulltext https://www.duo.uio.no/bitstream/handle/10852/84087/1/acs.orglett.0c00642.pdf
dc.type.version	PublishedVersion
dc.relation.project	NFR/250044
dc.relation.project	NFR/262695