dc.date.accessioned | 2021-03-10T21:12:09Z | |
dc.date.available | 2021-03-10T21:12:09Z | |
dc.date.created | 2020-11-14T18:55:25Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mitlid-Mork, Birgitte Bowe, Sophie Gran, Jon Michael Bolstad, Nils Berg, Jens Petter Redman, Christopher W.G. Staff, Anne Cathrine Sugulle, Meryam . Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study. PLOS ONE. 2020, 15:e0240473(10), 1-14 | |
dc.identifier.uri | http://hdl.handle.net/10852/83872 | |
dc.description.abstract | Background
Post-term pregnancies have increased risks for adverse fetal and maternal outcomes. Maternal concentrations of the placenta-associated proteins placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) have been identified as predictors for preeclampsia and fetal growth restriction, both syndromes of placental dysfunction. We have proposed that low maternal circulating PlGF and increased sFlt-1 are general markers for syncytiotrophoblast stress, which increases at and beyond term, even in apparently uncomplicated pregnancies. Our aim was to establish circulating PlGF, sFlt-1, and sFlt-1/PlGF reference ranges in healthy post-term pregnancies (gestational week ≥40+2), comparing with healthy term pregnancies and evaluating associations between time to delivery and biomarker percentiles.
Methods
Of 501 healthy, singleton post-term pregnancies prospectively recruited between September 2016 and December 2017 at our tertiary obstetric department, 426 with an uncomplicated delivery outcome contributed PlGF and sFlt-1 serum concentrations for reference range construction. A retrospective, cross-sectional, term group with an uncomplicated delivery outcome (n = 146) served as comparison. Differences in percentile values between groups and confidence intervals were calculated by quantile regression.
Results
In post-term pregnancies the 5th, 50th, and 95th percentiles for PlGF were: 70, 172, and 496 pg/mL; for sFlt-1: 2074, 4268, and 9141 pg/mL; and for sFlt-1/PlGF 5.3, 25.5, and 85.2. Quantile regression analyses comparing the post-term to the term group showed for PlGF a trend towards higher 10th through 30th percentiles, for sFlt-1 significantly higher 10th through 80th percentiles, and for sFlt-1/PlGF ratio significantly higher 30th percentile and significantly lower 95th percentile.
PlGF below the 5th percentile and sFlt-1/PlGF ratio above the 95th percentile was associated with shorter time to delivery (p = 0.031 and p = 0.025, respectively).
Conclusions
Our findings support the concept of increasing syncytiotrophoblast stress post-term in clinically healthy pregnancies. Whether post-term dysregulated angiogenic markers reflect a biological placental clock merits further investigation. | |
dc.language | EN | |
dc.publisher | PLOS | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study | |
dc.type | Journal article | |
dc.creator.author | Mitlid-Mork, Birgitte | |
dc.creator.author | Bowe, Sophie | |
dc.creator.author | Gran, Jon Michael | |
dc.creator.author | Bolstad, Nils | |
dc.creator.author | Berg, Jens Petter | |
dc.creator.author | Redman, Christopher W.G. | |
dc.creator.author | Staff, Anne Cathrine | |
dc.creator.author | Sugulle, Meryam | |
cristin.unitcode | 185,50,0,0 | |
cristin.unitname | Det medisinske fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1847980 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=15:e0240473&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | PLOS ONE | |
dc.identifier.volume | 15 | |
dc.identifier.issue | 10 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0240473 | |
dc.identifier.urn | URN:NBN:no-86596 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/83872/1/1847980.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0240473 | |