dc.date.accessioned | 2021-02-13T20:15:03Z | |
dc.date.available | 2021-02-27T23:45:54Z | |
dc.date.created | 2021-01-22T18:23:07Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Brunetti, Marta Zeller, Bernward Tierens, Anne Heim, Sverre Micci, Francesca Panagopoulos, Ioannis . TYRO3 truncation resulting from a t(10;15)(p11;q15) chromosomal translocation in pediatric acute myeloid leukemia. Anticancer Research. 2020, 40(11), 6115-6121 | |
dc.identifier.uri | http://hdl.handle.net/10852/83176 | |
dc.description.abstract | Background/Aim: Novel acquired chromosome aberrations in cancer may provide insights into pathogenetic mechanisms, be of diagnostic and/or prognostic significance and pave the way for new modes of therapeutic intervention. Here, we report a novel chromosome translocation and its molecular genetic consequences in a pediatric acute myeloid leukemia (AML) case. Materials and Methods: Cytogenetic, RNA sequencing, and molecular analyses were performed on the bone marrow cells of a child with AML. Results: The patient entered complete hematologic remission after treatment according to the NOPHO-AML 2004 protocol. A novel t(10;15)(p11;q15) translocation was found in leukemic cells at diagnosis resulting in a fusion of exon 13 of TYRO3 with a sequence from 10p11. The transcript codes for a putative TYRO3 protein lacking the tyrosine kinase domain. Conclusion: The t(10;15)(p11;q15) translocation in neoplastic bone marrow cells results in truncated TYRO3. Because the role of the truncated TYRO3 cannot be predicted functional studies are required. | |
dc.language | EN | |
dc.title | TYRO3 truncation resulting from a t(10;15)(p11;q15) chromosomal translocation in pediatric acute myeloid leukemia | |
dc.type | Journal article | |
dc.creator.author | Brunetti, Marta | |
dc.creator.author | Zeller, Bernward | |
dc.creator.author | Tierens, Anne | |
dc.creator.author | Heim, Sverre | |
dc.creator.author | Micci, Francesca | |
dc.creator.author | Panagopoulos, Ioannis | |
cristin.unitcode | 185,53,49,13 | |
cristin.unitname | Institutt for kreftgenetikk og informatikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1877479 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Anticancer Research&rft.volume=40&rft.spage=6115&rft.date=2020 | |
dc.identifier.jtitle | Anticancer Research | |
dc.identifier.volume | 40 | |
dc.identifier.issue | 11 | |
dc.identifier.startpage | 6115 | |
dc.identifier.endpage | 6121 | |
dc.identifier.doi | https://doi.org/10.21873/anticanres.14632 | |
dc.identifier.urn | URN:NBN:no-85940 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0250-7005 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/83176/1/TYRO3%2BTruncation%2BResulting%2BFrom%2Ba.pdf | |
dc.type.version | PublishedVersion | |