In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group
dc.date.accessioned | 2021-01-23T19:16:30Z | |
dc.date.available | 2021-01-23T19:16:30Z | |
dc.date.created | 2021-01-14T19:57:07Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Haukvik, Unn Kristin H. Gurholt, Tiril Pedersen Nerland, Stener Elvsåshagen, Torbjørn Akudjedu, Theophilus N. Alda, Martin Alnæs, Dag Alonso-Lana, Silvia Bauer, Jochen Baune, Bernhard T Benedetti, Francesco Berk, Michael Bettella, Francesco Bøen, Erlend Bonnín, C. M Brambilla, Paolo Canales-Rodriguez, Erick J. Cannon, Dara M Caseras, Xavier Dandash, Orwa Dannlowski, Udo Delvecchio, Giuseppe Díaz-Zuluaga, Ana M. van Erp, Theo GM Fatjo-Vilas, Mar Foley, Sonya F. Förster, Katharina Fullerton, Janice M. Goikolea, Jose M. Grotegerd, Dominik Gruber, Oliver Haarman, Bartholomeus CM Haatveit, Beathe Hajek, Tomas Hallahan, Brian Harris, Mathew Hawkins, Emma L. Howells, Fleur M Hülsmann, Carina Jahanshad, Neda Jørgensen, Kjetil Nordbø Kircher, Tilo Krämer, Bernd Krug, Axel Kuplicki, Rayus Lagerberg, Trine Vik Lancaster, Thomas M Lenroot, Rhoshel K. Lonning, Vera Lopez-Jaramillo, Carlos Malt, Ulrik Fredrik McDonald, Colm McIntosh, Andrew M. McPhilemy, Genevieve van der Meer, Dennis Melle, Ingrid Melloni, Elisa MT Mitchell, Philip B Nabulsi, Leila Nenadic, Igor Oertel, Viola Oldani, Lucio Opel, Nils Otaduy, Maria CG Overs, Bronwyn J. Pineda-Zapata, Julian A. Pomarol-Clotet, Edith Radua, Joaquim Rauer, Lisa Redlich, Ronny Repple, Jonathan Rive, Maria M Roberts, Gloria Ruhe, Henricus G Salminen, Lauren E. Salvador, Raymond Sarró, Salvador Savitz, Jonathan Schene, Aart H Sim, Kang Soeiro-de-Souza, Márcio Gerhardt Stablein, Michael Stein, Dan J Stein, Frederike Tamnes, Christian Krog Temmingh, Henk S Thomopoulos, Sophia I. Veltman, Dick J Vieta, Eduard Waltemate, Lena Westlye, Lars Tjelta Whalley, Heather C Sämann, Philipp G Thompson, Paul M Ching, Christopher RK Andreassen, Ole Andreas Agartz, Ingrid . In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/82543 | |
dc.description.abstract | The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta‐Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1‐weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed‐effects models and mega‐analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = −0.20), cornu ammonis (CA)1 (d = −0.18), CA2/3 (d = −0.11), CA4 (d = −0.19), molecular layer (d = −0.21), granule cell layer of dentate gyrus (d = −0.21), hippocampal tail (d = −0.10), subiculum (d = −0.15), presubiculum (d = −0.18), and hippocampal amygdala transition area (d = −0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non‐users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group | |
dc.type | Journal article | |
dc.creator.author | Haukvik, Unn Kristin H. | |
dc.creator.author | Gurholt, Tiril Pedersen | |
dc.creator.author | Nerland, Stener | |
dc.creator.author | Elvsåshagen, Torbjørn | |
dc.creator.author | Akudjedu, Theophilus N. | |
dc.creator.author | Alda, Martin | |
dc.creator.author | Alnæs, Dag | |
dc.creator.author | Alonso-Lana, Silvia | |
dc.creator.author | Bauer, Jochen | |
dc.creator.author | Baune, Bernhard T | |
dc.creator.author | Benedetti, Francesco | |
dc.creator.author | Berk, Michael | |
dc.creator.author | Bettella, Francesco | |
dc.creator.author | Bøen, Erlend | |
dc.creator.author | Bonnín, C. M | |
dc.creator.author | Brambilla, Paolo | |
dc.creator.author | Canales-Rodriguez, Erick J. | |
dc.creator.author | Cannon, Dara M | |
dc.creator.author | Caseras, Xavier | |
dc.creator.author | Dandash, Orwa | |
dc.creator.author | Dannlowski, Udo | |
dc.creator.author | Delvecchio, Giuseppe | |
dc.creator.author | Díaz-Zuluaga, Ana M. | |
dc.creator.author | van Erp, Theo GM | |
dc.creator.author | Fatjo-Vilas, Mar | |
dc.creator.author | Foley, Sonya F. | |
dc.creator.author | Förster, Katharina | |
dc.creator.author | Fullerton, Janice M. | |
dc.creator.author | Goikolea, Jose M. | |
dc.creator.author | Grotegerd, Dominik | |
dc.creator.author | Gruber, Oliver | |
dc.creator.author | Haarman, Bartholomeus CM | |
dc.creator.author | Haatveit, Beathe | |
dc.creator.author | Hajek, Tomas | |
dc.creator.author | Hallahan, Brian | |
dc.creator.author | Harris, Mathew | |
dc.creator.author | Hawkins, Emma L. | |
dc.creator.author | Howells, Fleur M | |
dc.creator.author | Hülsmann, Carina | |
dc.creator.author | Jahanshad, Neda | |
dc.creator.author | Jørgensen, Kjetil Nordbø | |
dc.creator.author | Kircher, Tilo | |
dc.creator.author | Krämer, Bernd | |
dc.creator.author | Krug, Axel | |
dc.creator.author | Kuplicki, Rayus | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Lancaster, Thomas M | |
dc.creator.author | Lenroot, Rhoshel K. | |
dc.creator.author | Lonning, Vera | |
dc.creator.author | Lopez-Jaramillo, Carlos | |
dc.creator.author | Malt, Ulrik Fredrik | |
dc.creator.author | McDonald, Colm | |
dc.creator.author | McIntosh, Andrew M. | |
dc.creator.author | McPhilemy, Genevieve | |
dc.creator.author | van der Meer, Dennis | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Melloni, Elisa MT | |
dc.creator.author | Mitchell, Philip B | |
dc.creator.author | Nabulsi, Leila | |
dc.creator.author | Nenadic, Igor | |
dc.creator.author | Oertel, Viola | |
dc.creator.author | Oldani, Lucio | |
dc.creator.author | Opel, Nils | |
dc.creator.author | Otaduy, Maria CG | |
dc.creator.author | Overs, Bronwyn J. | |
dc.creator.author | Pineda-Zapata, Julian A. | |
dc.creator.author | Pomarol-Clotet, Edith | |
dc.creator.author | Radua, Joaquim | |
dc.creator.author | Rauer, Lisa | |
dc.creator.author | Redlich, Ronny | |
dc.creator.author | Repple, Jonathan | |
dc.creator.author | Rive, Maria M | |
dc.creator.author | Roberts, Gloria | |
dc.creator.author | Ruhe, Henricus G | |
dc.creator.author | Salminen, Lauren E. | |
dc.creator.author | Salvador, Raymond | |
dc.creator.author | Sarró, Salvador | |
dc.creator.author | Savitz, Jonathan | |
dc.creator.author | Schene, Aart H | |
dc.creator.author | Sim, Kang | |
dc.creator.author | Soeiro-de-Souza, Márcio Gerhardt | |
dc.creator.author | Stablein, Michael | |
dc.creator.author | Stein, Dan J | |
dc.creator.author | Stein, Frederike | |
dc.creator.author | Tamnes, Christian Krog | |
dc.creator.author | Temmingh, Henk S | |
dc.creator.author | Thomopoulos, Sophia I. | |
dc.creator.author | Veltman, Dick J | |
dc.creator.author | Vieta, Eduard | |
dc.creator.author | Waltemate, Lena | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Whalley, Heather C | |
dc.creator.author | Sämann, Philipp G | |
dc.creator.author | Thompson, Paul M | |
dc.creator.author | Ching, Christopher RK | |
dc.creator.author | Andreassen, Ole Andreas | |
dc.creator.author | Agartz, Ingrid | |
cristin.unitcode | 185,53,10,14 | |
cristin.unitname | Enhet voksenpsykiatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1871616 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human Brain Mapping&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Human Brain Mapping | |
dc.identifier.doi | https://doi.org/10.1002/hbm.25249 | |
dc.identifier.urn | URN:NBN:no-85428 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1065-9471 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/82543/2/hbm.25249.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | hbm.25249 | |
dc.relation.project | NFR/2137000 | |
dc.relation.project | HSØ/2017097 | |
dc.relation.project | HSØ/2017112 | |
dc.relation.project | NFR/250358 | |
dc.relation.project | HSØ/2014097 | |
dc.relation.project | NFR/288083 | |
dc.relation.project | NFR/223273 | |
dc.relation.project | NOTUR/NORSTORE/NS9666S |
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