dc.date.accessioned | 2021-01-18T20:32:56Z | |
dc.date.available | 2021-01-18T20:32:56Z | |
dc.date.created | 2021-01-11T14:12:40Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Lopes-ramos, Camila Chen, Cho-Yi Kuijjer, Marieke Lydia Paulson, Joseph N. Sonawane, Abhijeet Fagny, Maud Platig, John Glass, Kimberly Quackenbush, John DeMeo, Dawn L. . Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues. Cell reports. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/82326 | |
dc.description.abstract | Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene regulatory networks in 29 human healthy tissues using 8,279 whole-genome expression profiles from the Genotype-Tissue Expression (GTEx) project. We find sex-biased regulatory network structures in each tissue. Even though most transcription factors (TFs) are not differentially expressed between males and females, many have sex-biased regulatory targeting patterns. In each tissue, genes that are differentially targeted by TFs between the sexes are enriched for tissue-related functions and diseases. In brain tissue, for example, genes associated with Parkinson’s disease and Alzheimer’s disease are targeted by different sets of TFs in each sex. Our systems-based analysis identifies a repertoire of TFs that play important roles in sex-specific architecture of gene regulatory networks, and it underlines sex-specific regulatory processes in both health and disease. | |
dc.language | EN | |
dc.publisher | Cell Press | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues | |
dc.type | Journal article | |
dc.creator.author | Lopes-ramos, Camila | |
dc.creator.author | Chen, Cho-Yi | |
dc.creator.author | Kuijjer, Marieke Lydia | |
dc.creator.author | Paulson, Joseph N. | |
dc.creator.author | Sonawane, Abhijeet | |
dc.creator.author | Fagny, Maud | |
dc.creator.author | Platig, John | |
dc.creator.author | Glass, Kimberly | |
dc.creator.author | Quackenbush, John | |
dc.creator.author | DeMeo, Dawn L. | |
cristin.unitcode | 185,57,55,0 | |
cristin.unitname | Marieke Kuijjer Group - Computational Biology and Systems Medicine | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1869085 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell reports&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Cell reports | |
dc.identifier.volume | 31 | |
dc.identifier.issue | 12 | |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2020.107795 | |
dc.identifier.urn | URN:NBN:no-85224 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2211-1247 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/82326/1/2020-06-23_lopes-ramos_cell_rep.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 107795 | |