dc.date.accessioned | 2020-11-17T19:46:37Z | |
dc.date.available | 2020-11-17T19:46:37Z | |
dc.date.created | 2020-11-13T20:21:45Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Moen, Gunn-Helen Brumpton, Ben Michael Willer, Cristen J. Åsvold, Bjørn Olav Birkeland, Kåre I. Wang, Geng Neale, Michael C. Freathy, Rachel M. Smith, George Davey Lawlor, Debbie A. Kirkpatrick, Robert M. Warrington, Nicole Maree Evans, David M. . Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort. Nature Communications. 2020, 11:5404, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/81064 | |
dc.description.abstract | Abstract
There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse environmental factors in utero increase future risk of cardiometabolic disease. Here, we explore if a genetic risk score (GRS) of maternal SNPs associated with offspring birthweight is also associated with offspring cardiometabolic risk factors, after controlling for offspring GRS, in up to 26,057 mother–offspring pairs (and 19,792 father–offspring pairs) from the Nord-Trøndelag Health (HUNT) Study. We find little evidence for a maternal (or paternal) genetic effect of birthweight associated variants on offspring cardiometabolic risk factors after adjusting for offspring GRS. In contrast, offspring GRS is strongly related to many cardiometabolic risk factors, even after conditioning on maternal GRS. Our results suggest that the maternal intrauterine environment, as proxied by maternal SNPs that influence offspring birthweight, is unlikely to be a major determinant of adverse cardiometabolic outcomes in population based samples of individuals. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort | |
dc.type | Journal article | |
dc.creator.author | Moen, Gunn-Helen | |
dc.creator.author | Brumpton, Ben Michael | |
dc.creator.author | Willer, Cristen J. | |
dc.creator.author | Åsvold, Bjørn Olav | |
dc.creator.author | Birkeland, Kåre I. | |
dc.creator.author | Wang, Geng | |
dc.creator.author | Neale, Michael C. | |
dc.creator.author | Freathy, Rachel M. | |
dc.creator.author | Smith, George Davey | |
dc.creator.author | Lawlor, Debbie A. | |
dc.creator.author | Kirkpatrick, Robert M. | |
dc.creator.author | Warrington, Nicole Maree | |
dc.creator.author | Evans, David M. | |
cristin.unitcode | 185,53,11,16 | |
cristin.unitname | Avdeling for endokrinologi, sykelig overvekt og forebyggende medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1847916 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=11:5404&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-020-19257-z | |
dc.identifier.urn | URN:NBN:no-84146 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/81064/1/Moen%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 5404 | |