dc.date.accessioned | 2020-11-13T18:55:58Z | |
dc.date.available | 2020-11-13T18:55:58Z | |
dc.date.created | 2020-11-02T13:28:42Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Lyngbakken, Magnus Berdal, Jan Erik Eskesen, Arne N Kvale, Dag Olsen, Inge Christoffer Rueegg, Corina Silvia Rangberg, Anbjørg Jonassen, Christine M Omland, Torbjørn Røsjø, Helge Dalgard, Olav . A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics. Nature Communications. 2020, 11:5284, 1-6 | |
dc.identifier.uri | http://hdl.handle.net/10852/81021 | |
dc.description.abstract | Abstract
Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study inclusion if they had moderately severe COVID-19 at admission. Treatment with hydroxychloroquine did not result in a significantly greater rate of decline in SARS-CoV-2 oropharyngeal viral load compared to standard care alone during the first five days. Our results suggest no important antiviral effect of hydroxychloroquine in humans infected with SARS-CoV-2. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics | |
dc.type | Journal article | |
dc.creator.author | Lyngbakken, Magnus | |
dc.creator.author | Berdal, Jan Erik | |
dc.creator.author | Eskesen, Arne N | |
dc.creator.author | Kvale, Dag | |
dc.creator.author | Olsen, Inge Christoffer | |
dc.creator.author | Rueegg, Corina Silvia | |
dc.creator.author | Rangberg, Anbjørg | |
dc.creator.author | Jonassen, Christine M | |
dc.creator.author | Omland, Torbjørn | |
dc.creator.author | Røsjø, Helge | |
dc.creator.author | Dalgard, Olav | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1844141 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=11:5284&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-020-19056-6 | |
dc.identifier.urn | URN:NBN:no-84118 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/81021/1/Lyngbakken%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 5284 | |