dc.date.accessioned | 2020-08-17T19:53:18Z | |
dc.date.available | 2020-08-17T19:53:18Z | |
dc.date.created | 2020-07-14T17:09:33Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Rahmati, Maryam Frank, Matthias Johannes Walter, Martin Sebastian Monjo Cabrer, Marta Satué, María Reseland, Janne Elin Lyngstadaas, Ståle Petter Haugen, Håvard Jostein . Osteoimmunomodulatory effects of enamel matrix derivate and strontium coating layers: A short- and long-term in vivo study. ACS Applied Bio Materials (AABM). 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/78480 | |
dc.description.abstract | Over the past few years, surface modification of implant surface has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several strategies for surface functionalization of titanium based implants, only few studies have compared the osteoimmunomodulatory effects of ionic nanostructure and biofunctionalization in the same biological model. Enamel matrix derivate (EMD) and strontium are both known for their positive influences on bone cell responses. In this study, we functionalized the titanium-zirconium implant surface with EMD and strontium using an electrochemical cathodic polarization method. Afterwards, we evaluated the osteoimmunomodulatory effects of EMD or strontium coated titanium zirconium implants in the tibia of eight Grey Bastard Chinchillas rabbits. We performed 2&3D micro-CT, wound fluid, histologic, and histomorphometric analyses on bone tissues after 4- and 8-weeks implantation. Although the results could indicate some differences between groups regarding the bone quality, there was no difference in bone amount or volume. EMD stimulated higher ALP activity and lower cytotoxicity in wound fluid, as well as a lower expression of inflammatory markers after 8 weeks indicating its osteoimmunomodulatory effects after implantation. Overall, the results suggested that ionic nanostructure modification and biofunctionalization might be useful in regulating the immune responses to implants. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Osteoimmunomodulatory effects of enamel matrix derivate and strontium coating layers: A short- and long-term in vivo study | |
dc.type | Journal article | |
dc.creator.author | Rahmati, Maryam | |
dc.creator.author | Frank, Matthias Johannes | |
dc.creator.author | Walter, Martin Sebastian | |
dc.creator.author | Monjo Cabrer, Marta | |
dc.creator.author | Satué, María | |
dc.creator.author | Reseland, Janne Elin | |
dc.creator.author | Lyngstadaas, Ståle Petter | |
dc.creator.author | Haugen, Håvard Jostein | |
cristin.unitcode | 185,16,17,62 | |
cristin.unitname | Biomaterialer | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1819428 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ACS Applied Bio Materials (AABM)&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | ACS Applied Bio Materials (AABM) | |
dc.identifier.doi | https://doi.org/10.1021/acsabm.0c00608 | |
dc.identifier.urn | URN:NBN:no-81542 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2576-6422 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/78480/4/acsabm.0c00608.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | acsabm.0c00608 | |