Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma

dc.date.accessioned	2020-08-17T19:05:35Z
dc.date.available	2020-08-17T19:05:35Z
dc.date.created	2020-05-29T13:55:16Z
dc.date.issued	2020
dc.identifier.citation	Pandey, Sushma Osman, Tarig Al-Hadi Sharma, Sunita Vallenari, Evan Michael Shahdafar, Aboulghassem Pun, Chin B. Gautam, Dej K. Uhlin-Hansen, Lars Rikardsen, Oddveig G Johannessen, Anne Christine Costea, Daniela Elena Sapkota, Dipak . Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Head and Neck. 2020, 1-11
dc.identifier.uri	http://hdl.handle.net/10852/78457
dc.description.abstract	Background We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in OSCC. Methods S100A14 expression was examined in 170 OSCCs from Norwegian and Nepalese populations using immunohistochemistry. Pro‐differentiation function was investigated by overexpressing and silencing S100A14 expression in OSCC‐derived cells. External transcriptomic datasets were used to validate association between S100A14 and differentiation markers in OSCC. Result Loss of S100A14 expression at the invading tumor fronts significantly correlated with poor differentiation and reduced 10‐years survival of OSCC‐patients. Multivariate Cox analysis identified S100A14 to be an independent prognostic factor. Modulation of S100A14 expression in OSCC‐derived cells positively correlated with the expression of differentiation markers. Analysis of external datasets supported the pro‐differentiation function of S100A14. Conclusion These results indicate that S100A14 is a pro‐differentiation protein and its expression might be useful as a prognostic marker in OSCC.
dc.language	EN
dc.publisher	Wiley-Interscience Publishers
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.title	Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
dc.type	Journal article
dc.creator.author	Pandey, Sushma
dc.creator.author	Osman, Tarig Al-Hadi
dc.creator.author	Sharma, Sunita
dc.creator.author	Vallenari, Evan Michael
dc.creator.author	Shahdafar, Aboulghassem
dc.creator.author	Pun, Chin B.
dc.creator.author	Gautam, Dej K.
dc.creator.author	Uhlin-Hansen, Lars
dc.creator.author	Rikardsen, Oddveig G
dc.creator.author	Johannessen, Anne Christine
dc.creator.author	Costea, Daniela Elena
dc.creator.author	Sapkota, Dipak
cristin.unitcode	185,16,15,0
cristin.unitname	Institutt for oral biologi
cristin.ispublished	true
cristin.fulltext	original
cristin.qualitycode	2
dc.identifier.cristin	1813255
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Head and Neck&rft.volume=&rft.spage=1&rft.date=2020
dc.identifier.jtitle	Head and Neck
dc.identifier.volume	42
dc.identifier.issue	8
dc.identifier.startpage	2088
dc.identifier.endpage	2098
dc.identifier.doi	https://doi.org/10.1002/hed.26140
dc.identifier.urn	URN:NBN:no-81580
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	1043-3074
dc.identifier.fulltext	Fulltext https://www.duo.uio.no/bitstream/handle/10852/78457/1/hed.26140.pdf
dc.type.version	PublishedVersion