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dc.date.accessioned2020-08-14T18:11:51Z
dc.date.available2020-08-14T18:11:51Z
dc.date.created2020-07-14T16:59:54Z
dc.date.issued2020
dc.identifier.citationRahmati, Maryam silva, eduardo a. Reseland, Janne Elin Heyward, Catherine Anne Haugen, Håvard Jostein . Biological responses to physicochemical properties of biomaterial surface. Chemical Society Reviews. 2020
dc.identifier.urihttp://hdl.handle.net/10852/78359
dc.description.abstractBiomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface.
dc.languageEN
dc.rightsAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleBiological responses to physicochemical properties of biomaterial surface
dc.typeJournal article
dc.creator.authorRahmati, Maryam
dc.creator.authorsilva, eduardo a.
dc.creator.authorReseland, Janne Elin
dc.creator.authorHeyward, Catherine Anne
dc.creator.authorHaugen, Håvard Jostein
cristin.unitcode185,16,17,62
cristin.unitnameBiomaterialer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1819427
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemical Society Reviews&rft.volume=&rft.spage=&rft.date=2020
dc.identifier.jtitleChemical Society Reviews
dc.identifier.volume49
dc.identifier.issue15
dc.identifier.startpage5178
dc.identifier.endpage5224
dc.identifier.doihttps://doi.org/10.1039/D0CS00103A
dc.identifier.urnURN:NBN:no-81495
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0306-0012
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/78359/2/chem%2Bsoc%2Brev.pdf
dc.type.versionPublishedVersion
dc.relation.projectEC/H2020/811226


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