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Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin

dc.date.accessioned2020-07-13T18:33:42Z
dc.date.available2020-07-13T18:33:42Z
dc.date.created2019-10-10T12:34:22Z
dc.date.issued2019
dc.identifier.citationPeeters, Sara Berntsen, Linn Neerbye Rongved, Pål Bonge-Hansen, Tore . Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin. Beilstein Journal of Organic Chemistry. 2019, 15, 2156-2160
dc.identifier.urihttp://hdl.handle.net/10852/77846
dc.description.abstractWe present a short and efficient way of synthesizing two synthetically versatile 4-quinolone-3-carboxylate building blocks by cyclopropanation-ring expansion of 3-chloroindoles with α-halodiazoacetates as the key step. This novel transformation was applied towards the synthesis of the antibiotic drug norfloxacin.
dc.languageEN
dc.publisherBeilstein-Institut
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin
dc.typeJournal article
dc.creator.authorPeeters, Sara
dc.creator.authorBerntsen, Linn Neerbye
dc.creator.authorRongved, Pål
dc.creator.authorBonge-Hansen, Tore
cristin.unitcode185,15,12,0
cristin.unitnameKjemisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1735954
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Beilstein Journal of Organic Chemistry&rft.volume=15&rft.spage=2156&rft.date=2019
dc.identifier.jtitleBeilstein Journal of Organic Chemistry
dc.identifier.volume15
dc.identifier.startpage2156
dc.identifier.endpage2160
dc.identifier.doihttps://doi.org/10.3762/bjoc.15.212
dc.identifier.urnURN:NBN:no-80943
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2195-951X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/77846/1/Saras_Norfloxacin.pdf
dc.type.versionPublishedVersion


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