dc.date.accessioned | 2020-07-07T18:42:20Z | |
dc.date.available | 2020-07-07T18:42:20Z | |
dc.date.created | 2020-01-16T14:40:16Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Sundberg, Jonas Korytowska, Magdalena Holmberg, Erik Bratel, John Wallström, Mats Kjellstrom, Ebba Blomgren, Johan Kovacs, Aniko Öhman, Jenny Sand, Lars Peter Hirsch, Jan-Michael Giglio, Daniel Kjeller, Göran Hasseus, Bengt . Recurrence rates after surgical removal of oral leukoplakia-A prospective longitudinal multicentre study. PLOS ONE. 2019, 14(12) | |
dc.identifier.uri | http://hdl.handle.net/10852/77582 | |
dc.description.abstract | Oral leukoplakia (OL) is a potentially malignant oral disorder. The Gold Standard treatment is to remove surgically the OL. Despite optimal surgery, the recurrence rates are estimated to be 30%. The reason for this is unknown. The aim of this study was to investigate the clinical factors that correlate with recurrence after surgical removal of OL. In a prospective study data were collected from 226 patients with OL. Forty-six patients were excluded due to incomplete records or concomitant presence of other oral mucosal diseases. Overall, 180 patients proceeded to analysis (94 women and 86 men; mean age, 62 years; age range, 28–92 years). Clinical data, such as gender, diagnosis (homogeneous/non-homogeneous leukoplakia), location, size, tobacco and alcohol use, verified histopathological diagnosis, and clinical photograph, were obtained. In patients who were eligible for surgery, the OL was surgically removed with a margin. To establish recurrence, a healthy mucosa between the surgery and recurrence had to be confirmed in the records or clinical photographs. Statistical analysis was performed with the level of significance set at P<0.05. Of the 180 patients diagnosed with OL, 57% (N = 103) underwent surgical removal in toto. Recurrence was observed in 43 OL. The cumulative incidence of recurrence of OL was 45% after 4 years and 49% after 5 years. Fifty-six percent (N = 23) of the non-homogeneous type recurred. Among snuff-users 73% (N = 8) cases of OL recurred. A non-homogeneous type of OL and the use of snuff were significantly associated with recurrence after surgical excision (P = 0.021 and P = 0.003, respectively). Recurrence was also significantly associated with cancer transformation (P<0.001). No significant differences were found between recurrence and any of the following: dysplasia, site of lesion, size, multiple vs. solitary OL, gender, age, use of alcohol or smoking. In conclusion, clinical factors that predict recurrence of OL are non-homogeneous type and use of snuff. | en_US |
dc.language | EN | |
dc.publisher | PLOS | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Recurrence rates after surgical removal of oral leukoplakia-A prospective longitudinal multicentre study | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Sundberg, Jonas | |
dc.creator.author | Korytowska, Magdalena | |
dc.creator.author | Holmberg, Erik | |
dc.creator.author | Bratel, John | |
dc.creator.author | Wallström, Mats | |
dc.creator.author | Kjellstrom, Ebba | |
dc.creator.author | Blomgren, Johan | |
dc.creator.author | Kovacs, Aniko | |
dc.creator.author | Öhman, Jenny | |
dc.creator.author | Sand, Lars Peter | |
dc.creator.author | Hirsch, Jan-Michael | |
dc.creator.author | Giglio, Daniel | |
dc.creator.author | Kjeller, Göran | |
dc.creator.author | Hasseus, Bengt | |
cristin.unitcode | 185,16,15,0 | |
cristin.unitname | Institutt for oral biologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1775018 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=14&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | PLOS ONE | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 12 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0225682 | |
dc.identifier.urn | URN:NBN:no-80713 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77582/2/LarsPeterSandartikkel.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0225682 | |