dc.date.accessioned | 2020-06-29T19:16:41Z | |
dc.date.available | 2020-06-29T19:16:41Z | |
dc.date.created | 2019-12-19T12:45:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Brynildsen, Jon Myhre, Peder Langeland Lyngbakken, Magnus Klæboe, Lars Gunnar Stridsberg, Mats Christensen, Geir Arve Edvardsen, Thor Omland, Torbjørn Røsjø, Helge . Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis. Clinical Biochemistry. 2019, 71, 17-23 | |
dc.identifier.uri | http://hdl.handle.net/10852/77320 | |
dc.description.abstract | Background
Secretoneurin (SN) concentrations provide important prognostic information in patients with myocardial dysfunction. Whether preoperative SN concentrations improve risk assessment in patients with moderate to severe aortic stenosis (AS) is unknown.
Methods
We included 57 patients with moderate to severe AS referred for presurgical evaluation. All patients were examined with comprehensive echocardiography, electrocardiogram (ECG), and biochemical measurements and compared to 10 age- and sex-matched healthy subjects.
Results
Median (quartile 1–3) SN concentrations were 141 (121–163) pmol/L in AS patients and 132 (106–148) pmol/L in control subjects (p = .17). Lower estimated creatinine clearance and use of diuretics, but not standard ECG or echocardiographic indices and cardiac biomarkers, were associated with increasing SN concentrations. Fifteen patients (26%) died during 3.5 years median follow-up. SN concentrations were higher in non-survivors than survivors: 156 (133–209) vs. 140 (116–155) pmol/L, p = .007. Higher SN concentrations were associated with increased risk of mortality also after adjustment for established risk indices, biomarkers, and status regarding valvular surgery: hazard ratio per lnSN 15.13 (95% CI 1.05–219.00); p = .046. Receiver operating characteristics area under the curve for SN to predict mortality was 0.74 (95% CI 0.60–0.88) compared to 0.73 (0.59–0.87) for high-sensitivity cardiac troponin T and 0.67 (0.51–0.82) for N-terminal pro-B-type natriuretic peptide. The previously identified cut-off of SN >204 pmol/L in cardiac surgical patients predicted mortality also in this cohort.
Conclusions
SN concentrations improve risk assessment in patients with moderate to severe AS by providing additional prognostic information to established risk indices such as echocardiography, ECG, and established cardiac biomarkers. | en_US |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Brynildsen, Jon | |
dc.creator.author | Myhre, Peder Langeland | |
dc.creator.author | Lyngbakken, Magnus | |
dc.creator.author | Klæboe, Lars Gunnar | |
dc.creator.author | Stridsberg, Mats | |
dc.creator.author | Christensen, Geir Arve | |
dc.creator.author | Edvardsen, Thor | |
dc.creator.author | Omland, Torbjørn | |
dc.creator.author | Røsjø, Helge | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1762946 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical Biochemistry&rft.volume=71&rft.spage=17&rft.date=2019 | |
dc.identifier.jtitle | Clinical Biochemistry | |
dc.identifier.volume | 71 | |
dc.identifier.startpage | 17 | |
dc.identifier.endpage | 23 | |
dc.identifier.doi | https://doi.org/10.1016/j.clinbiochem.2019.06.008 | |
dc.identifier.urn | URN:NBN:no-80380 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0009-9120 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77320/1/AS_SN_graniner_ms_ClinBiochem_postprint.pdf | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77320/2/AS_SN_graniner_Suppl_ClinBiochem_postprint.pdf | |
dc.type.version | AcceptedVersion | |