dc.date.accessioned | 2020-06-22T18:37:29Z | |
dc.date.available | 2020-06-22T18:37:29Z | |
dc.date.created | 2020-02-20T09:13:53Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | du Pré, Fleur Blazevski, Jana Dewan, Alisa Elinsdatter Stamnæs, Jorunn Kanduri, Chakravarthi Sandve, Geir Kjetil Johannesen, Marie Kongshaug Lindstad, Christian Borgen Hnida, Kathrin Fugger, Lars Melino, Gerry Qiao, Shuo-Wang Sollid, Ludvig Magne . B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.. Journal of Experimental Medicine. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/77127 | |
dc.description.abstract | Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient–derived anti-TG2 B cell receptor equally reactive to human and mouse TG2. We studied B cell development in the presence/absence of autoantigen by crossing the Ig KI mice to Tgm2−/− mice. Autoreactive B cells in Tgm2+/+ mice were indistinguishable from their naive counterparts in Tgm2−/− mice with no signs of clonal deletion, receptor editing, or B cell anergy. The autoreactive B cells appeared ignorant to their antigen, and they produced autoantibodies when provided T cell help. The findings lend credence to a model of celiac disease where gluten-reactive T cells provide help to autoreactive TG2-specific B cells by involvement of gluten–TG2 complexes, and they outline a general mechanism of autoimmunity with autoantibodies being produced by ignorant B cells on provision of T cell help. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.title | B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. | |
dc.type | Journal article | |
dc.creator.author | du Pré, Fleur | |
dc.creator.author | Blazevski, Jana | |
dc.creator.author | Dewan, Alisa Elinsdatter | |
dc.creator.author | Stamnæs, Jorunn | |
dc.creator.author | Kanduri, Chakravarthi | |
dc.creator.author | Sandve, Geir Kjetil | |
dc.creator.author | Johannesen, Marie Kongshaug | |
dc.creator.author | Lindstad, Christian Borgen | |
dc.creator.author | Hnida, Kathrin | |
dc.creator.author | Fugger, Lars | |
dc.creator.author | Melino, Gerry | |
dc.creator.author | Qiao, Shuo-Wang | |
dc.creator.author | Sollid, Ludvig Magne | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1795969 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Experimental Medicine&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Journal of Experimental Medicine | |
dc.identifier.volume | 217 | |
dc.identifier.issue | 2 | |
dc.identifier.doi | https://doi.org/10.1084/jem.20190860 | |
dc.identifier.urn | URN:NBN:no-80232 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0022-1007 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77127/1/du%2BPre%2BJEM%2B2019.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e20190860 | |