Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
dc.date.accessioned | 2020-06-19T19:42:18Z | |
dc.date.available | 2020-06-19T19:42:18Z | |
dc.date.created | 2019-05-28T14:42:24Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Warrington, Nicole Maree Beaumont, Robin N. Horikoshi, Momoko Day, Felix R. Helgeland, Øyvind Laurin, Charles Bacelis, Jonas Peng, Shouneng Hao, Ke Feenstra, Bjarke Wood, Andrew R. Mahajan, Anubha Tyrrell, Jessica Robertson, Neil R. Rayner, N William Qiao, Zhen Moen, Gunn-Helen Vaudel, Marc Marsit, Carmen J. Chen, Jia Nodzenski, Michael Schnurr, Theresia M. Zafarmand, Mohammad H. Bradfield, Jonathan P. Grarup, Niels Kooijman, Marjolein N. Li-Gao, Ruifang Geller, Frank Ahluwalia, Tarunveer S. Paternoster, Lavinia Rueedi, Rico Huikari, Ville Hottenga, Jouke-Jan Lyytikäinen, Leo-Pekka Cavadino, Alana Metrustry, Sarah Cousminer, Diana L. Wu, Ying Thiering, Elisabeth Wang, Carol A. Have, Christian T. Vilor-Tejedor, Natalia Joshi, Peter K. Painter, Jodie N. Ntalla, Ioanna Myhre, Ronny Pitkänen, Niina van Leeuwen, Elisabeth M. Joro, Raimo Lagou, Vasiliki Richmond, Rebecca C. Espinosa, Ana Barton, Sheila J. Inskip, Hazel M. Holloway, John W. Santa-Marina, Loreto Estivill, Xavier Ang, Wei Marsh, Julie A. Reichetzeder, Christoph Marullo, Letizia Hocher, Berthold Lunetta, Kathryn L. Murabito, Joanne M. Relton, Caroline L. Kogevinas, Manolis Chatzi, Leda Allard, Catherine Bouchard, Luigi Hivert, Marie-France Zhang, Ge Muglia, Louis J. Heikkinen, Jani Morgen, Camilla S. van Kampen, Antoine H.C. van Schaik, Barbera D.C. Mentch, Frank D. Langenberg, Claudia Luan, Jian'an Scott, Robert A. Zhao, Jing Hua Hemani, Gibran Ring, Susan M. Bennett, Amanda J. Gaulton, Kyle J. Fernandez-Tajes, Juan van Zuydam, Natalie R. Medina-Gomez, Carolina de Haan, Hugoline Georgette Rosendaal, Frits Richard Kutalik, Zoltán Marques-Vidal, Pedro Das, Shikta Willemsen, Gonneke Mbarek, Hamdi Müller-Nurasyid, Martina Standl, Marie Appel, Emil V.R. Fonvig, Cilius E. Trier, Caecilie van Beijsterveldt, Catharina E.M. Murcia, Mario Bustamante, Mariona Bonas-Guarch, Silvia Hougaard, David M. Mercader, Josep M. Linneberg, Allan Schraut, Katharina E. Lind, Penelope A. Medland, Sarah E. Shields, Beverley M. Knight, Bridget A. Chai, Jin-Fang Panoutsopoulou, Kalliope Bartels, Meike Sanchez, Friman Stokholm, Jakob Torrents, David Vinding, Rebecca K. Willems, Sara M. Atalay, Mustafa Chawes, Bo L. Kovacs, Peter Prokopenko, Inga Tuke, Marcus A. Yaghootkar, Hanieh Ruth, Katherine S. Jones, Samuel E. Loh, Po-Ru Murray, Anna Weedon, Michael N. Tönjes, Anke Stumvoll, Michael Michaelsen, Kim F. Eloranta, Aino-Maija Lakka, Timo A. van Duijn, Cornelia M. Kiess, Wieland Körner, Antje Niinikoski, Harri Pahkala, Katja Raitakari, Olli T. Jacobsson, Bo Zeggini, Eleftheria Dedoussis, George V. Teo, Yik-Ying Saw, Seang-Mei Montgomery, Grant W. Campbell, Harry Wilson, James F. Vrijkotte, Tanja G.M. Vrijheid, Martine de Geus, Eco J.C.N. Hayes, M. Geoffrey Kadarmideen, Haja N. Holm, Jens-Christian Beilin, Lawrence J. Pennell, Craig E. Heinrich, Joachim Adair, Linda S. Borja, Judith B. Mohlke, Karen L. Eriksson, Johan G. Widén, Elisabeth Hattersley, Andrew T. Spector, Tim D. Kähönen, Mika Viikari, Jorma S. Lehtimäki, Terho Boomsma, Dorret I. Sebert, Sylvain Vollenweider, Peter Sørensen, Thorkild I.A. Bisgaard, Hans Bønnelykke, Klaus Murray, Jeffrey C. Melbye, Mads Nohr, Ellen A. Mook-Kanamori, Dennis O. Rivadeneira, Fernando Hofman, Albert Felix, Janine F. Jaddoe, Vincent W V Hansen, Torben Pisinger, Charlotta Vaag, Allan A. Pedersen, Oluf Uitterlinden, André G. Järvelin, Marjo-Riitta Power, Christine Hyppönen, Elina Scholtens, Denise M. Lowe, William L. Davey Smith, George Timpson, Nicholas J. Morris, Andrew P. Wareham, Nicholas J. Hakonarson, Hakon Grant, Struan F.A. Frayling, Timothy M. Lawlor, Debbie A. Njølstad, Pål Rasmus Johansson, Stefan Ong, Ken K. McCarthy, Mark I. Perry, John R.B. Evans, David M. Freathy, Rachel M. . Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature Genetics. 2019, 51(5), 804-814 | |
dc.identifier.uri | http://hdl.handle.net/10852/77102 | |
dc.description.abstract | Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight–blood pressure association is attributable to genetic effects, and not to intrauterine programming. | |
dc.language | EN | |
dc.title | Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors | |
dc.type | Journal article | |
dc.creator.author | Warrington, Nicole Maree | |
dc.creator.author | Beaumont, Robin N. | |
dc.creator.author | Horikoshi, Momoko | |
dc.creator.author | Day, Felix R. | |
dc.creator.author | Helgeland, Øyvind | |
dc.creator.author | Laurin, Charles | |
dc.creator.author | Bacelis, Jonas | |
dc.creator.author | Peng, Shouneng | |
dc.creator.author | Hao, Ke | |
dc.creator.author | Feenstra, Bjarke | |
dc.creator.author | Wood, Andrew R. | |
dc.creator.author | Mahajan, Anubha | |
dc.creator.author | Tyrrell, Jessica | |
dc.creator.author | Robertson, Neil R. | |
dc.creator.author | Rayner, N William | |
dc.creator.author | Qiao, Zhen | |
dc.creator.author | Moen, Gunn-Helen | |
dc.creator.author | Vaudel, Marc | |
dc.creator.author | Marsit, Carmen J. | |
dc.creator.author | Chen, Jia | |
dc.creator.author | Nodzenski, Michael | |
dc.creator.author | Schnurr, Theresia M. | |
dc.creator.author | Zafarmand, Mohammad H. | |
dc.creator.author | Bradfield, Jonathan P. | |
dc.creator.author | Grarup, Niels | |
dc.creator.author | Kooijman, Marjolein N. | |
dc.creator.author | Li-Gao, Ruifang | |
dc.creator.author | Geller, Frank | |
dc.creator.author | Ahluwalia, Tarunveer S. | |
dc.creator.author | Paternoster, Lavinia | |
dc.creator.author | Rueedi, Rico | |
dc.creator.author | Huikari, Ville | |
dc.creator.author | Hottenga, Jouke-Jan | |
dc.creator.author | Lyytikäinen, Leo-Pekka | |
dc.creator.author | Cavadino, Alana | |
dc.creator.author | Metrustry, Sarah | |
dc.creator.author | Cousminer, Diana L. | |
dc.creator.author | Wu, Ying | |
dc.creator.author | Thiering, Elisabeth | |
dc.creator.author | Wang, Carol A. | |
dc.creator.author | Have, Christian T. | |
dc.creator.author | Vilor-Tejedor, Natalia | |
dc.creator.author | Joshi, Peter K. | |
dc.creator.author | Painter, Jodie N. | |
dc.creator.author | Ntalla, Ioanna | |
dc.creator.author | Myhre, Ronny | |
dc.creator.author | Pitkänen, Niina | |
dc.creator.author | van Leeuwen, Elisabeth M. | |
dc.creator.author | Joro, Raimo | |
dc.creator.author | Lagou, Vasiliki | |
dc.creator.author | Richmond, Rebecca C. | |
dc.creator.author | Espinosa, Ana | |
dc.creator.author | Barton, Sheila J. | |
dc.creator.author | Inskip, Hazel M. | |
dc.creator.author | Holloway, John W. | |
dc.creator.author | Santa-Marina, Loreto | |
dc.creator.author | Estivill, Xavier | |
dc.creator.author | Ang, Wei | |
dc.creator.author | Marsh, Julie A. | |
dc.creator.author | Reichetzeder, Christoph | |
dc.creator.author | Marullo, Letizia | |
dc.creator.author | Hocher, Berthold | |
dc.creator.author | Lunetta, Kathryn L. | |
dc.creator.author | Murabito, Joanne M. | |
dc.creator.author | Relton, Caroline L. | |
dc.creator.author | Kogevinas, Manolis | |
dc.creator.author | Chatzi, Leda | |
dc.creator.author | Allard, Catherine | |
dc.creator.author | Bouchard, Luigi | |
dc.creator.author | Hivert, Marie-France | |
dc.creator.author | Zhang, Ge | |
dc.creator.author | Muglia, Louis J. | |
dc.creator.author | Heikkinen, Jani | |
dc.creator.author | Morgen, Camilla S. | |
dc.creator.author | van Kampen, Antoine H.C. | |
dc.creator.author | van Schaik, Barbera D.C. | |
dc.creator.author | Mentch, Frank D. | |
dc.creator.author | Langenberg, Claudia | |
dc.creator.author | Luan, Jian'an | |
dc.creator.author | Scott, Robert A. | |
dc.creator.author | Zhao, Jing Hua | |
dc.creator.author | Hemani, Gibran | |
dc.creator.author | Ring, Susan M. | |
dc.creator.author | Bennett, Amanda J. | |
dc.creator.author | Gaulton, Kyle J. | |
dc.creator.author | Fernandez-Tajes, Juan | |
dc.creator.author | van Zuydam, Natalie R. | |
dc.creator.author | Medina-Gomez, Carolina | |
dc.creator.author | de Haan, Hugoline Georgette | |
dc.creator.author | Rosendaal, Frits Richard | |
dc.creator.author | Kutalik, Zoltán | |
dc.creator.author | Marques-Vidal, Pedro | |
dc.creator.author | Das, Shikta | |
dc.creator.author | Willemsen, Gonneke | |
dc.creator.author | Mbarek, Hamdi | |
dc.creator.author | Müller-Nurasyid, Martina | |
dc.creator.author | Standl, Marie | |
dc.creator.author | Appel, Emil V.R. | |
dc.creator.author | Fonvig, Cilius E. | |
dc.creator.author | Trier, Caecilie | |
dc.creator.author | van Beijsterveldt, Catharina E.M. | |
dc.creator.author | Murcia, Mario | |
dc.creator.author | Bustamante, Mariona | |
dc.creator.author | Bonas-Guarch, Silvia | |
dc.creator.author | Hougaard, David M. | |
dc.creator.author | Mercader, Josep M. | |
dc.creator.author | Linneberg, Allan | |
dc.creator.author | Schraut, Katharina E. | |
dc.creator.author | Lind, Penelope A. | |
dc.creator.author | Medland, Sarah E. | |
dc.creator.author | Shields, Beverley M. | |
dc.creator.author | Knight, Bridget A. | |
dc.creator.author | Chai, Jin-Fang | |
dc.creator.author | Panoutsopoulou, Kalliope | |
dc.creator.author | Bartels, Meike | |
dc.creator.author | Sanchez, Friman | |
dc.creator.author | Stokholm, Jakob | |
dc.creator.author | Torrents, David | |
dc.creator.author | Vinding, Rebecca K. | |
dc.creator.author | Willems, Sara M. | |
dc.creator.author | Atalay, Mustafa | |
dc.creator.author | Chawes, Bo L. | |
dc.creator.author | Kovacs, Peter | |
dc.creator.author | Prokopenko, Inga | |
dc.creator.author | Tuke, Marcus A. | |
dc.creator.author | Yaghootkar, Hanieh | |
dc.creator.author | Ruth, Katherine S. | |
dc.creator.author | Jones, Samuel E. | |
dc.creator.author | Loh, Po-Ru | |
dc.creator.author | Murray, Anna | |
dc.creator.author | Weedon, Michael N. | |
dc.creator.author | Tönjes, Anke | |
dc.creator.author | Stumvoll, Michael | |
dc.creator.author | Michaelsen, Kim F. | |
dc.creator.author | Eloranta, Aino-Maija | |
dc.creator.author | Lakka, Timo A. | |
dc.creator.author | van Duijn, Cornelia M. | |
dc.creator.author | Kiess, Wieland | |
dc.creator.author | Körner, Antje | |
dc.creator.author | Niinikoski, Harri | |
dc.creator.author | Pahkala, Katja | |
dc.creator.author | Raitakari, Olli T. | |
dc.creator.author | Jacobsson, Bo | |
dc.creator.author | Zeggini, Eleftheria | |
dc.creator.author | Dedoussis, George V. | |
dc.creator.author | Teo, Yik-Ying | |
dc.creator.author | Saw, Seang-Mei | |
dc.creator.author | Montgomery, Grant W. | |
dc.creator.author | Campbell, Harry | |
dc.creator.author | Wilson, James F. | |
dc.creator.author | Vrijkotte, Tanja G.M. | |
dc.creator.author | Vrijheid, Martine | |
dc.creator.author | de Geus, Eco J.C.N. | |
dc.creator.author | Hayes, M. Geoffrey | |
dc.creator.author | Kadarmideen, Haja N. | |
dc.creator.author | Holm, Jens-Christian | |
dc.creator.author | Beilin, Lawrence J. | |
dc.creator.author | Pennell, Craig E. | |
dc.creator.author | Heinrich, Joachim | |
dc.creator.author | Adair, Linda S. | |
dc.creator.author | Borja, Judith B. | |
dc.creator.author | Mohlke, Karen L. | |
dc.creator.author | Eriksson, Johan G. | |
dc.creator.author | Widén, Elisabeth | |
dc.creator.author | Hattersley, Andrew T. | |
dc.creator.author | Spector, Tim D. | |
dc.creator.author | Kähönen, Mika | |
dc.creator.author | Viikari, Jorma S. | |
dc.creator.author | Lehtimäki, Terho | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Sebert, Sylvain | |
dc.creator.author | Vollenweider, Peter | |
dc.creator.author | Sørensen, Thorkild I.A. | |
dc.creator.author | Bisgaard, Hans | |
dc.creator.author | Bønnelykke, Klaus | |
dc.creator.author | Murray, Jeffrey C. | |
dc.creator.author | Melbye, Mads | |
dc.creator.author | Nohr, Ellen A. | |
dc.creator.author | Mook-Kanamori, Dennis O. | |
dc.creator.author | Rivadeneira, Fernando | |
dc.creator.author | Hofman, Albert | |
dc.creator.author | Felix, Janine F. | |
dc.creator.author | Jaddoe, Vincent W V | |
dc.creator.author | Hansen, Torben | |
dc.creator.author | Pisinger, Charlotta | |
dc.creator.author | Vaag, Allan A. | |
dc.creator.author | Pedersen, Oluf | |
dc.creator.author | Uitterlinden, André G. | |
dc.creator.author | Järvelin, Marjo-Riitta | |
dc.creator.author | Power, Christine | |
dc.creator.author | Hyppönen, Elina | |
dc.creator.author | Scholtens, Denise M. | |
dc.creator.author | Lowe, William L. | |
dc.creator.author | Davey Smith, George | |
dc.creator.author | Timpson, Nicholas J. | |
dc.creator.author | Morris, Andrew P. | |
dc.creator.author | Wareham, Nicholas J. | |
dc.creator.author | Hakonarson, Hakon | |
dc.creator.author | Grant, Struan F.A. | |
dc.creator.author | Frayling, Timothy M. | |
dc.creator.author | Lawlor, Debbie A. | |
dc.creator.author | Njølstad, Pål Rasmus | |
dc.creator.author | Johansson, Stefan | |
dc.creator.author | Ong, Ken K. | |
dc.creator.author | McCarthy, Mark I. | |
dc.creator.author | Perry, John R.B. | |
dc.creator.author | Evans, David M. | |
dc.creator.author | Freathy, Rachel M. | |
cristin.unitcode | 185,53,11,16 | |
cristin.unitname | Avdeling for endokrinologi, sykelig overvekt og forebyggende medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1700929 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Genetics&rft.volume=51&rft.spage=804&rft.date=2019 | |
dc.identifier.jtitle | Nature Genetics | |
dc.identifier.volume | 51 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 804 | |
dc.identifier.endpage | 814 | |
dc.identifier.doi | https://doi.org/10.1038/s41588-019-0403-1 | |
dc.identifier.urn | URN:NBN:no-80189 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1061-4036 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77102/1/Maternal%2Band%2Bfetal%2Bgenetic%2Beffects%2Bon%2Bbirth%2Bweight%2Band%2Btheir%2Brelevance%2Bto%2Bcardio-metabolic%2Brisk%2Bfactor.pdf | |
dc.type.version | AcceptedVersion |
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